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Anti-Phospho-KDM4B (Thr305) Polyclonal Antibody
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Catalog No. TMAB-10893
Anti-Phospho-KDM4B (Thr305) Polyclonal Antibody is a Rabbit antibody targeting Phospho-KDM4B (Thr305). Anti-Phospho-KDM4B (Thr305) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Anti-Phospho-KDM4B (Thr305) Polyclonal Antibody
Anti-Phospho-KDM4B (Thr305) Polyclonal Antibody
😃Good
Catalog No. TMAB-10893
Anti-Phospho-KDM4B (Thr305) Polyclonal Antibody is a Rabbit antibody targeting Phospho-KDM4B (Thr305). Anti-Phospho-KDM4B (Thr305) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $222 | 7-10 days | 7-10 days | |
| 100 μL | $371 | 7-10 days | 7-10 days | |
| 200 μL | $527 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-Phospho-KDM4B (Thr305) Polyclonal Antibody is a Rabbit antibody targeting Phospho-KDM4B (Thr305). Anti-Phospho-KDM4B (Thr305) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF. |
| Ig Type | IgG |
| Reactivity | Mouse,Rat (predicted:Human,Dog,Cow,Sheep) |
| Application | |
| Recommended Dose | IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Nucleus. Chromosome. Associates with euchromatic regions. Does not associate with heterochromatin. |
| Tissue Specificity | Expressed in all tissues examined, with high levels in fetal liver, thymus, lymph node, spleen and peripheral blood leukocytes and lower level in bone marrow. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | Enables histone H3-methyl-lysine-36 demethylase activity and histone H3-methyl-lysine-9 demethylase activity. Involved in histone H3-K36 demethylation and histone H3-K9 demethylation. Located in cytosol and nucleoplasm. Implicated in autosomal dominant non-syndromic intellectual disability; breast cancer; colorectal cancer; malignant peripheral nerve sheath tumor; and stomach cancer. Biomarker of several diseases, including alopecia areata; lung cancer; medulloblastoma; prostate cancer; and stomach cancer. [provided by Alliance of Genome Resources, Apr 2022] |
| Immunogen | KLH conjugated synthesised phosphopeptide: human JMJD2B around the phosphorylation site of Thr305 |
| Antigen Species | Human |
| Gene Name | KDM4B |
| Gene ID | |
| Protein Name | Lysine-specific demethylase 4B |
| Uniprot ID | |
| Function | Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate. |
| Molecular Weight | Theoretical: 122 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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