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Cucurbit[8]uril

Catalog No. T35862 CAS 259886-51-6

Cucurbit[8]uril is a highly effective and safe supramolecular compound that promotes protein heterodimerization. It selectively induces the heterodimerization of methylviologen and naphthalene functionalized proteins, demonstrating its specificity and versatility. Additionally, Cucurbit[8]uril shows exceptional oral activity and low toxicity, making it a promising candidate for various pharmaceutical and biotechnological applications.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Cucurbit[8]uril, CAS 259886-51-6

Pack Size	Availability	Price/USD
5 mg	In stock	$ 41.00
10 mg	In stock	$ 57.00
25 mg	In stock	$ 148.00
50 mg	In stock	$ 232.00
100 mg	In stock	$ 348.00

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Purity: 98.74%

Biological Description

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Storage & Solubility Information

Description	Cucurbit[8]uril is a highly effective and safe supramolecular compound that promotes protein heterodimerization. It selectively induces the heterodimerization of methylviologen and naphthalene functionalized proteins, demonstrating its specificity and versatility. Additionally, Cucurbit[8]uril shows exceptional oral activity and low toxicity, making it a promising candidate for various pharmaceutical and biotechnological applications.
In vitro	Cucurbit[8]uril (0~20 μM; 48 hours; CHO-K1 cells) makes the relative cell viability dropped marginally to 86%[2].Cucurbit[8]uril indeed selectively induces the heterodimerization of MV-eYFP with Np-eCFP. Cucurbit[8]uril-induced high energy transfer between the proteins is only observed in the presence of all three supramolecular components, allowing the formation of the ternary complex. In the presence of Cucurbit[8]uril, the unspecific protein assembly induced by the methylviologen is inhibited. The ternary system of Cucurbit[8]uril with methylviologen (MV) and naphthalene (NP) can also be successfully used for the formation of selective protein heterodimers of more hydrophobic proteins. The presence of Cucurbit[8]uril as a host molecule is required to prevent MV induced unspecific dimerization with hydrophobic protein surfaces[1].
In vivo	Cucurbit[8]uril exhibits minimal toxicity when administered either intravenously or orally in mice, as demonstrated by in vivo studies[2].

Molecular Weight	1329.1
Formula	C48H48N32O16
CAS No.	259886-51-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: < 1 mg/mL

References and Literature

1. Uhlenheuer DA, et al. Cucurbit[8]uril induced heterodimerization of methylviologen and naphthalene functionalized proteins. Chem Commun (Camb). 2011;47(24):6798-6800. 2. Uzunova VD, et al. Toxicity of cucurbit[7]uril and cucurbit[8]uril: an exploratory in vitro and in vivo study. Org Biomol Chem. 2010;8(9):2037-2042.

Related compound libraries

This product is contained In the following compound libraries：

Orally Active Compound Library Bioactive Compounds Library Max Macrocyclic Compound Library Human Metabolite Library Bioactive Compound Library

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Keywords

Cucurbit[8]uril 259886-51-6 Others inhibit methylviologen heterodimerization naphthalene potent supramolecular orally Inhibitor low-toxicity inhibitor

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