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Cefazaflur

Name: Cefazaflur
Brand: TargetMol
SKU: T67977
Price: 46 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T67977Cas No. 58665-96-6

Cefazaflur is a novel semi-synthetic cephalosporin derivative that can be used as an Antibiotic agent.

Cefazaflur

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Purity: 99.14%

Catalog No. T67977Cas No. 58665-96-6

Cefazaflur is a novel semi-synthetic cephalosporin derivative that can be used as an Antibiotic agent.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$46	In Stock	In Stock
5 mg	$113	In Stock	In Stock
10 mg	$168	In Stock	In Stock
25 mg	$281	In Stock	In Stock
50 mg	$398	In Stock	In Stock
100 mg	$541	-	In Stock
200 mg	$691	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.14%

ee:100%

Appearance:Solid

Color:White to Yellow

Resource Download

COA LCMS CSFC FNMR HNMR

Product Introduction

Bioactivity

Description

Cefazaflur is a novel semi-synthetic cephalosporin derivative that can be used as an Antibiotic agent.

In vitro

Cefazaflur was tested in vitro against 262 strains of bacteria. When tested in agar, 5.0 mug or less of cefazaflur per ml inhibited almost all strains of Staphylococcus aureus, Escherichia coli, Klebsiella, and Proteus mirabilis. The drug was less active against Enterobacter and indole-positive Proteus, and 7.5 mug of antibiotic per ml inhibited approximately two-thirds to one-fourth of the strains. A concentration of 50 mug of cefazaflur per ml was required for inhibition of the enterococci. There was negligible activity against Pseudomonas. The drug demonstrated less activity in broth than in agar, and a major inoculum effect was seen with some strains. For example, with a lower inoculum, 2.5 mug of cefazaflur per ml killed all strains of E. coli, whereas with the higher inoculum, 7.5 mug of cefazaflur per ml, inhibited 64% and killed only 8% of strains.[1]

Chemical Properties

Molecular Weight	470.47
Formula	C₁₃H₁₃F₃N₆O₄S₃
Cas No.	58665-96-6
Smiles	C(O)(=O)C=1N2[C@@]([C@H](NC(CSC(F)(F)F)=O)C2=O)(SCC1CSC=3N(C)N=NN3)[H]

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (106.28 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1255 mL	10.6277 mL	21.2553 mL	106.2767 mL
5 mM	0.4251 mL	2.1255 mL	4.2511 mL	21.2553 mL
10 mM	0.2126 mL	1.0628 mL	2.1255 mL	10.6277 mL
20 mM	0.1063 mL	0.5314 mL	1.0628 mL	5.3138 mL
50 mM	0.0425 mL	0.2126 mL	0.4251 mL	2.1255 mL
100 mM	0.0213 mL	0.1063 mL	0.2126 mL	1.0628 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc