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Sulfo-SMCC sodium

Name: Sulfo-SMCC sodium
Brand: TargetMol
SKU: T18728
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T18728Cas No. 92921-24-9

Sulfo-SMCC sodium, a widely utilized non-cleavable, hetero-bifunctional crosslinker for antibody-drug conjugates (ADCs), features both N-hydroxysuccinimide (NHS) ester and maleimide groups. These functionalities enable it to specifically react with primary amines and sulfhydryl groups, respectively.

Sulfo-SMCC sodium

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Purity: 99.9%

Catalog No. T18728Cas No. 92921-24-9

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$41	In Stock	In Stock
25 mg	$58	In Stock	In Stock
50 mg	$74	In Stock	In Stock
100 mg	$97	-	In Stock
200 mg	$162	-	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.9%

Appearance:Solid

Color:White

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description

In vitro

Sulfo-SMCC, a crosslinker featuring a maleimide group and an N-hydroxysuccinimide ester, is designed to attach to sulfhydryl groups and primary amines, respectively. It effectively prevents the longitudinal fusion of stabilized Microtubules (MTs), which retain a consistent mean length regardless of incubation duration. This has been demonstrated in experiments where MTs, upon treatment with 250 μM Sulfo-SMCC, were observed at intervals of 0 hours, 6 hours, and 24 hours, showing no change in length over time[1].

Chemical Properties

Molecular Weight	436.37
Formula	C₁₆H₁₇N₂NaO₉S
Cas No.	92921-24-9
Smiles	[Na+].[O-]S(=O)(=O)[C@H]1CC(=O)N(OC(=O)C2CCC(CN3C(=O)C=CC3=O)CC2)C1=O
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from direct sunlight,keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 12 mg/mL (27.5 mM), Sonication is recommended.

DMSO: 83.33 mg/mL (190.96 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (9.17 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2916 mL	11.4582 mL	22.9163 mL	114.5817 mL
5 mM	0.4583 mL	2.2916 mL	4.5833 mL	22.9163 mL
10 mM	0.2292 mL	1.1458 mL	2.2916 mL	11.4582 mL
20 mM	0.1146 mL	0.5729 mL	1.1458 mL	5.7291 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0458 mL	0.2292 mL	0.4583 mL	2.2916 mL
100 mM	0.0229 mL	0.1146 mL	0.2292 mL	1.1458 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc