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Saccharin

Name: Saccharin
Brand: TargetMol
SKU: T0889
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0889Cas No. 81-07-2

Alias Saccharimide, O-Sulfobenzimide, O-Benzoic sulfimide, Benzoic sulfimide

Saccharin (O-Sulfobenzimide) is a flavoring agent and non-nutritive sweetener.

Saccharin

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Purity: 98.51%

Catalog No. T0889Alias Saccharimide, O-Sulfobenzimide, O-Benzoic sulfimide, Benzoic sulfimideCas No. 81-07-2

Saccharin (O-Sulfobenzimide) is a flavoring agent and non-nutritive sweetener.

Pack Size	Price	USA Warehouse	Global Warehouse
1 g	$31	In Stock	In Stock
5 g	$56	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.51%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Saccharin AI Summary

Saccharin exhibits multiple bioactivities across various biological targets. It demonstrates significant hypolipidemic activity in CF1 male mice, reducing serum triglycerides by 51% at a dosage of 20 mg/kg on the 14th day and lowering serum cholesterol by 68% on the 9th day and by 67% on the 16th day. It potentiates sweet taste with an intensity parameter of 1.0 relative to 10% sucrose and shows potent sweetness with potency values of 300 on a weight basis and 180 on a molar basis at 330 ppm. Despite this, it also exhibits some bitterness with a sensory score of 12.0. Regarding its activity as a carbonic anhydrase inhibitor, Saccharin displays varying inhibitory potencies against different isoforms. It inhibits human carbonic anhydrase 1 and 2 with Ki values of 18,540 nM and 5,950 nM, respectively. Notably, it exhibits strong inhibition against carbonic anhydrase 9 with a Ki of 103.0 nM and carbonic anhydrase 7 with a Ki of 10.0 nM. Additionally, it shows moderate inhibition against other isoforms such as carbonic anhydrase 12 (Ki = 633.0 nM). Its broad spectrum also includes inhibiting carbonic anhydrase from various organisms like Porphyromonas gingivalis, Trypanosoma cruzi, and Streptococcus mutans. In antiviral assays, Saccharin demonstrated activity against SARS-CoV-2, inhibiting viral-induced cytotoxicity in Caco-2 and VERO-6 cells. However, its efficacy varied with an IC50 value greater than 20,000 nM. Additionally, it showed a 37.77% inhibition of SARS-CoV-2-induced cytotoxicity at 10 μM after 48 hours. This compound also displays drug-like properties, such as an oral bioavailability of 84.0% in humans, a rapid elimination half-life of 1.11 hours, and a Cmax of 163,327.69 nM in ICR mice at a 30 mg/kg dose. Despite its diverse bioactivities, Saccharin exhibits no anti-inflammatory activity and presents moderate liver toxicity markers, indicating a need for careful consideration in therapeutic contexts..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Saccharin (O-Sulfobenzimide) is a flavoring agent and non-nutritive sweetener.
Synonyms	Saccharimide, O-Sulfobenzimide, O-Benzoic sulfimide, Benzoic sulfimide

Chemical Properties

Molecular Weight	183.18
Formula	C₇H₅NO₃S
Cas No.	81-07-2
Smiles	O=C1NS(=O)(=O)C2=CC=CC=C12
Relative Density.	0.793 g/cm3. Temperature:20 °C.

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (327.55 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (10.92 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.4591 mL	27.2956 mL	54.5911 mL	272.9556 mL
5 mM	1.0918 mL	5.4591 mL	10.9182 mL	54.5911 mL
10 mM	0.5459 mL	2.7296 mL	5.4591 mL	27.2956 mL
20 mM	0.2730 mL	1.3648 mL	2.7296 mL	13.6478 mL
50 mM	0.1092 mL	0.5459 mL	1.0918 mL	5.4591 mL
100 mM	0.0546 mL	0.2730 mL	0.5459 mL	2.7296 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc