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Anti-DHRS11 Polyclonal Antibody

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Catalog No. TMAB-05128

Anti-DHRS11 Polyclonal Antibody is a Rabbit antibody targeting DHRS11. Anti-DHRS11 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.

Anti-DHRS11 Polyclonal Antibody

Anti-DHRS11 Polyclonal Antibody

😃Good
Catalog No. TMAB-05128
Anti-DHRS11 Polyclonal Antibody is a Rabbit antibody targeting DHRS11. Anti-DHRS11 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
50 μL$2237-10 days7-10 days
100 μL$3727-10 days7-10 days
200 μL$5277-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Anti-DHRS11 Polyclonal Antibody is a Rabbit antibody targeting DHRS11. Anti-DHRS11 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
Reactivity
Human (predicted:Mouse,Rat,Pig,Cow,Horse,Sheep)
Application
Recommended Dose
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
Antibody Type
Polyclonal
Host SpeciesRabbit
Subcellular LocalizationSecreted.
ConstructionPolyclonal Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1mg/ml
Research BackgroundDHRS11 is a 260 amino acid secreted protein. Belonging to the short-chain dehydrogenases/reductases (SDR) family, DHRS11 forms a homotetramer and is expressed as two isoforms produced by alternative splicing events. The gene that encodes DHRS11 maps to human chromosome 17, which makes up over 2.5% of the human genome with about 81 million bases encoding over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes. Chromosome 17 is also linked to neurofibromatosis, a condition characterized by neural and epidermal lesions, and dysregulated Schwann cell growth. Alexander disease, Birt-Hogg-Dube syndrome and Canavan disease are also associated with chromosome 17.
Antigen Details
Immunogen
KLH conjugated synthetic peptide: human DHRS11
Antigen Species
Human
Gene Name
DHRS11
Gene ID
Protein Name
Dehydrogenase/reductase SDR family member 11
Uniprot ID
Chemical Properties
Molecular WeightTheoretical: 35 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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