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Iminostilbene

Name: Iminostilbene
Brand: TargetMol
SKU: T0598
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0598Cas No. 256-96-2

Alias Dibenzazepine

Iminostilbene (Dibenzazepine) (Dibenzazepine) is a chemical precursor of carbamazepine which is used primarily in the treatment of epilepsy and neuropathic pain.

Iminostilbene

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Purity: 98.50%

Catalog No. T0598Alias DibenzazepineCas No. 256-96-2

Iminostilbene (Dibenzazepine) (Dibenzazepine) is a chemical precursor of carbamazepine which is used primarily in the treatment of epilepsy and neuropathic pain.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 g	$29	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:98.50%

Appearance:Solid

Color:Yellow

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COA HNMR LCMS

Product Introduction

Iminostilbene AI Summary

Iminostilbene shows a broad spectrum of bioactivities and potential therapeutic applications. It inhibits AAPH-induced hemolysis in human erythrocytes in a dose-dependent manner, highlighting its protective effects against oxidative damage. The compound exhibits inhibitory effects in multiple assays, such as ATPase activity of TAg, Tau fibril formation, ROR gamma transcriptional activity, lipid storage in Drosophila cells, human alpha-Glucosidase activity, JMJD2A-Tudor Domain, Histone Lysine Methyltransferase G9a, BAZ2B, Polymerase Iota, MgcRacGAP, integrin-mediated alleviation for muscular dystrophy, human tyrosyl-DNA phosphodiesterase 1, and PTHR. Moreover, Iminostilbene demonstrates limited cytotoxic activity against UV-irradiated human U937 cells with an IC50 of 2580.0 nM and against human HepG2 cells with an IC50 value greater than 158489.32 nM in a 48-hour CCK8 assay. The compound also possesses antibacterial activity, inhibiting Escherichia coli and Pseudomonas aeruginosa to some extent, while showing minimal effects against Klebsiella pneumoniae, Staphylococcus aureus, and Acinetobacter baumannii. Additionally, Iminostilbene exhibits antifungal activity against Candida albicans but not against Cryptococcus neoformans. These diverse bioactivities suggest that Iminostilbene has potential uses in treating various diseases and biological pathways..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Iminostilbene (Dibenzazepine) (Dibenzazepine) is a chemical precursor of carbamazepine which is used primarily in the treatment of epilepsy and neuropathic pain.
Synonyms	Dibenzazepine

Chemical Properties

Molecular Weight	193.24
Formula	C₁₄H₁₁N
Cas No.	256-96-2
Smiles	N1C2=CC=CC=C2C=CC2=C1C=CC=C2
Relative Density.	1.116 g/cm3

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: Limited solubility

DMSO: 50 mg/mL (258.75 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (10.35 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.1749 mL	25.8746 mL	51.7491 mL	258.7456 mL
5 mM	1.0350 mL	5.1749 mL	10.3498 mL	51.7491 mL
10 mM	0.5175 mL	2.5875 mL	5.1749 mL	25.8746 mL
20 mM	0.2587 mL	1.2937 mL	2.5875 mL	12.9373 mL
50 mM	0.1035 mL	0.5175 mL	1.0350 mL	5.1749 mL
100 mM	0.0517 mL	0.2587 mL	0.5175 mL	2.5875 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc