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Anti-Thrombomodulin Polyclonal Antibody 2
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Catalog No. TMAB-13520
Anti-Thrombomodulin Polyclonal Antibody 2 is a Rabbit antibody targeting Thrombomodulin. Anti-Thrombomodulin Polyclonal Antibody 2 can be used in WB.
Anti-Thrombomodulin Polyclonal Antibody 2
Anti-Thrombomodulin Polyclonal Antibody 2
😃Good
Catalog No. TMAB-13520
Anti-Thrombomodulin Polyclonal Antibody 2 is a Rabbit antibody targeting Thrombomodulin. Anti-Thrombomodulin Polyclonal Antibody 2 can be used in WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $220 | 7-10 days | 7-10 days | |
| 100 μL | $374 | 7-10 days | 7-10 days | |
| 200 μL | $528 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-Thrombomodulin Polyclonal Antibody 2 is a Rabbit antibody targeting Thrombomodulin. Anti-Thrombomodulin Polyclonal Antibody 2 can be used in WB. |
| Ig Type | IgG |
| Reactivity | Human (predicted:Mouse,Dog,Cow,Sheep) |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Membrane; Single-pass type I membrane protein. |
| Tissue Specificity | Endothelial cells are unique in synthesizing thrombomodulin. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | Preservative: 0.02% Proclin300, Constituents: 1% BSA, 0.01M PBS, pH7.4. |
| Concentration | 1mg/ml |
| Research Background | Thrombomodulin, TM is cell surface glycoprotein; plays an important role in the protein C anticoagulant pathway. It located in a vein, artery and capillary endothelial cells on the surface of plasma membrane protein. It is generally believed: TM vascular endothelial injury is an important parameter is the thrombin receptor, known in a variety of normal human tissues, can also be expressed in many tumors, TM may be similar to the E-cadherin,and is a lectin Like activity of a new class of members of the cell adhesion molecules. CD141/Thrombomodulin is an exclusively endothelial cell surface glycoprotein that forms a 1:1 complex with thrombin. Binding of thrombin to this high-affinity receptor alters its specificity toward several substrates. The complex activates protein C approximately 1000 times faster than thrombin alone. Activated protein C degrades clotting factors V and VIII; thus, thrombomodulin converts thrombin into a physiologic anticoagulant. Thrombomodulin is also found in the circulatory and urinary systems, the physiologic significance of this is obscure. |
| Immunogen | KLH conjugated synthetic peptide: human Thrombomodulin |
| Antigen Species | Human |
| Gene Name | THBD |
| Gene ID | |
| Protein Name | Thrombomodulin |
| Uniprot ID | |
| Function | Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated. |
| Molecular Weight | Theoretical: 61 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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