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Ecteinascidin 770

Name: Ecteinascidin 770
Brand: TargetMol
SKU: T11150
Price: 198 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T11150Cas No. 114899-80-8

Alias Et-770, Et770, Ecteinascidine 770

Ecteinascidin 770 inhibits SARS-CoV-2 and Mycobacterium tuberculosis by inhibiting cancer cell viability through RDRP1 (RNA-dependent RNA polymerase 1).

Ecteinascidin 770

🥰Excellent

Purity: 99.84%

Catalog No. T11150Alias Et-770, Et770, Ecteinascidine 770Cas No. 114899-80-8

Ecteinascidin 770 inhibits SARS-CoV-2 and Mycobacterium tuberculosis by inhibiting cancer cell viability through RDRP1 (RNA-dependent RNA polymerase 1).

Pack Size	Price	Availability
1 mg	$198	In Stock
5 mg	$493	In Stock
10 mg	$732	In Stock
25 mg	$1,130	In Stock
50 mg	$1,530	In Stock
100 mg	$1,980	In Stock
1 mL x 10 mM (in DMSO)	$689	In Stock

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Purity:99.84%

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COA LCMS HNMR

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity

Description	Ecteinascidin 770 inhibits SARS-CoV-2 and Mycobacterium tuberculosis by inhibiting cancer cell viability through RDRP1 (RNA-dependent RNA polymerase 1).
Targets&IC50	HCT116 cells:0.6 nM, U373MG cells:4.83 nM, DU145 cells:0.81 nM
In vitro	Methods: U373MG glioblastoma cells were treated with Ecteinascidin 770, and cytotoxicity was detected by MTT assay. Results: The IC 50 value of Ecteinascidin 770 against U373MG cells was 4.83 nM. [1]
Alias	Et-770, Et770, Ecteinascidine 770

Chemical Properties

Molecular Weight	770.85
Formula	C₄₀H₄₂N₄O₁₀S
Cas No.	114899-80-8
Smiles	C(#N)[C@@H]1N2[C@@]([C@]3(C=4C([C@@]2(COC(=O)[C@@]5(CS3)C=6C(=CC(O)=C(OC)C6)CCN5)[H])=C7C(=C(C)C4OC(C)=O)OCO7)[H])([C@]8(C=9C(C[C@@]1(N8C)[H])=CC(C)=C(OC)C9O)[H])[H]
Relative Density.	1.53 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (51.89 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.2973 mL	6.4863 mL	12.9727 mL	64.8635 mL
5 mM	0.2595 mL	1.2973 mL	2.5945 mL	12.9727 mL
10 mM	0.1297 mL	0.6486 mL	1.2973 mL	6.4863 mL
20 mM	0.0649 mL	0.3243 mL	0.6486 mL	3.2432 mL
50 mM	0.0259 mL	0.1297 mL	0.2595 mL	1.2973 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc