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Ecteinascidin 770
🥰Excellent
Catalog No. T11150Cas No. 114899-80-8
Alias Et-770, Ecteinascidine 770
Ecteinascidin 770 (ET-770) inhibits U373MG cells and is a 1,2,3, 4-tetrahydroisoquinoline alkaloid with strong anticancer activity.IC50 is 4.83 nM.
Ecteinascidin 770
🥰Excellent
Catalog No. T11150Alias Et-770, Ecteinascidine 770Cas No. 114899-80-8
Ecteinascidin 770 (ET-770) inhibits U373MG cells and is a 1,2,3, 4-tetrahydroisoquinoline alkaloid with strong anticancer activity.IC50 is 4.83 nM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 mg | $1,538 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Ecteinascidin 770 (ET-770) inhibits U373MG cells and is a 1,2,3, 4-tetrahydroisoquinoline alkaloid with strong anticancer activity.IC50 is 4.83 nM. |
| Targets&IC50 | U373MG cells:4.83 nM |
| In vitro | ET-770 (Ecteinascidin 770) significantly enhances the anoikis response in human lung cancer H23 and H460 cells by activating p53 protein. This activation leads to the down-regulation of anti-apoptotic myeloid cell leukemia sequence-1 (MCL1) and up-regulation of BCL2-associated X protein (BAX), while B-cell lymphoma-2 (BCL2) proteins remain largely unaffected. Additionally, ET-770 induces apoptosis in U373MG glioblastoma cells, with an IC50 value of 4.83 nM after a 72-hour treatment, as determined by the MTT assay. The IC50 values for HCT116, QG56, and DU145 human cell lines are found to be 0.6, 2.4, and 0.81 nM, respectively, showcasing its apoptotic effectiveness across various cell types in a dose-dependent manner. |
| Alias | Et-770, Ecteinascidine 770 |
| Molecular Weight | 770.85 |
| Formula | C40H42N4O10S |
| Cas No. | 114899-80-8 |
| Relative Density. | 1.53 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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