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Ecteinascidin 770

🥰Excellent
Catalog No. T11150Cas No. 114899-80-8
Alias Et-770, Et770, Ecteinascidine 770

Ecteinascidin 770 inhibits SARS-CoV-2 and Mycobacterium tuberculosis by inhibiting cancer cell viability through RDRP1 (RNA-dependent RNA polymerase 1).

Ecteinascidin 770

Ecteinascidin 770

🥰Excellent
Purity: 99.84%
Catalog No. T11150Alias Et-770, Et770, Ecteinascidine 770Cas No. 114899-80-8
Ecteinascidin 770 inhibits SARS-CoV-2 and Mycobacterium tuberculosis by inhibiting cancer cell viability through RDRP1 (RNA-dependent RNA polymerase 1).
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$196-In Stock
5 mg$489-In Stock
10 mg$723-In Stock
25 mg$1,120-In Stock
50 mg$1,520-In Stock
100 mg$1,970-In Stock
1 mL x 10 mM (in DMSO)$613-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Batch Information

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Purity:99.84%
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Product Introduction

Bioactivity
Description
Ecteinascidin 770 inhibits SARS-CoV-2 and Mycobacterium tuberculosis by inhibiting cancer cell viability through RDRP1 (RNA-dependent RNA polymerase 1).
Targets&IC50
HCT116 cells:0.6 nM, U-373MG cells:4.83 nM, DU-145 cells:0.81 nM
In vitro
Methods: U373MG glioblastoma cells were treated with Ecteinascidin 770, and cytotoxicity was detected by MTT assay.
Results: The IC 50 value of Ecteinascidin 770 against U373MG cells was 4.83 nM. [1]
SynonymsEt-770, Et770, Ecteinascidine 770
Chemical Properties
Molecular Weight770.85
FormulaC40H42N4O10S
Cas No.114899-80-8
SmilesC(#N)[C@@H]1N2[C@@]([C@]3(C=4C([C@@]2(COC(=O)[C@@]5(CS3)C=6C(=CC(O)=C(OC)C6)CCN5)[H])=C7C(=C(C)C4OC(C)=O)OCO7)[H])([C@]8(C=9C(C[C@@]1(N8C)[H])=CC(C)=C(OC)C9O)[H])[H]
Relative Density.1.53 g/cm3 (Predicted)
ColorWhite
AppearanceSolid
Storage & Solubility Information
Storagekeep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 40 mg/mL (51.89 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (2.59 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.2973 mL6.4863 mL12.9727 mL64.8635 mL
5 mM0.2595 mL1.2973 mL2.5945 mL12.9727 mL
10 mM0.1297 mL0.6486 mL1.2973 mL6.4863 mL
20 mM0.0649 mL0.3243 mL0.6486 mL3.2432 mL
50 mM0.0259 mL0.1297 mL0.2595 mL1.2973 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

U373MG cellEcteinascidin 770
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