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Ecteinascidin 770

🥰Excellent
Catalog No. T11150Cas No. 114899-80-8
Alias Et-770, Et770, Ecteinascidine 770

Ecteinascidin 770 inhibits SARS-CoV-2 and Mycobacterium tuberculosis by inhibiting cancer cell viability through RDRP1 (RNA-dependent RNA polymerase 1).

Ecteinascidin 770

Ecteinascidin 770

🥰Excellent
Purity: 99.84%
Catalog No. T11150Alias Et-770, Et770, Ecteinascidine 770Cas No. 114899-80-8
Ecteinascidin 770 inhibits SARS-CoV-2 and Mycobacterium tuberculosis by inhibiting cancer cell viability through RDRP1 (RNA-dependent RNA polymerase 1).
Pack SizePriceAvailabilityQuantity
1 mg$198In Stock
5 mg$493In Stock
10 mg$732In Stock
25 mg$1,130In Stock
50 mg$1,530In Stock
100 mg$1,980In Stock
1 mL x 10 mM (in DMSO)$689In Stock
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Purity:99.84%
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Product Introduction

Bioactivity
Description
Ecteinascidin 770 inhibits SARS-CoV-2 and Mycobacterium tuberculosis by inhibiting cancer cell viability through RDRP1 (RNA-dependent RNA polymerase 1).
Targets&IC50
HCT116 cells:0.6 nM, U373MG cells:4.83 nM, DU145 cells:0.81 nM
In vitro
Methods: U373MG glioblastoma cells were treated with Ecteinascidin 770, and cytotoxicity was detected by MTT assay.
Results: The IC 50 value of Ecteinascidin 770 against U373MG cells was 4.83 nM. [1]
AliasEt-770, Et770, Ecteinascidine 770
Chemical Properties
Molecular Weight770.85
FormulaC40H42N4O10S
Cas No.114899-80-8
SmilesC(#N)[C@@H]1N2[C@@]([C@]3(C=4C([C@@]2(COC(=O)[C@@]5(CS3)C=6C(=CC(O)=C(OC)C6)CCN5)[H])=C7C(=C(C)C4OC(C)=O)OCO7)[H])([C@]8(C=9C(C[C@@]1(N8C)[H])=CC(C)=C(OC)C9O)[H])[H]
Relative Density.1.53 g/cm3 (Predicted)
Storage & Solubility Information
Storagekeep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 40 mg/mL (51.89 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.2973 mL6.4863 mL12.9727 mL64.8635 mL
5 mM0.2595 mL1.2973 mL2.5945 mL12.9727 mL
10 mM0.1297 mL0.6486 mL1.2973 mL6.4863 mL
20 mM0.0649 mL0.3243 mL0.6486 mL3.2432 mL
50 mM0.0259 mL0.1297 mL0.2595 mL1.2973 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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