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Pitofenone hydrochloride

Name: Pitofenone hydrochloride
Brand: TargetMol
SKU: T4466
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4466Cas No. 1248-42-6

Alias Pitophenone hydrochloride, Baralgin Ketone Hydrochloride

Pitofenone hydrochloride (Pitophenone hydrochloride), a spasmolytic compound, inhibits the acetylcholinesterase (AChE) activity from bovine erythrocytes and from electric eel with Kis of 36 and 45 μM, respectively.

Pitofenone hydrochloride

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Purity: 99.97%

Catalog No. T4466Alias Pitophenone hydrochloride, Baralgin Ketone HydrochlorideCas No. 1248-42-6

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$43	In Stock	In Stock
25 mg	$98	In Stock	In Stock
50 mg	$187	In Stock	In Stock
100 mg	$352	In Stock	In Stock
200 mg	$492	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.97%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Pitofenone hydrochloride AI Summary

Pitofenone hydrochloride has been evaluated for its bioactivity across various assays, demonstrating notable potency in inhibiting human tyrosyl-DNA phosphodiesterase 1 (TDP1), as well as in affecting cellular binding or entry of Marburg and Ebola viruses. AC50 values for the compound range between 14.13 μM and 35481.3 nM, indicating varied levels of potency. These findings suggest that Pitofenone hydrochloride holds promise for further exploration as both an antiviral agent and an enzyme inhibitor..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Pitofenone hydrochloride (Pitophenone hydrochloride), a spasmolytic compound, inhibits the acetylcholinesterase (AChE) activity from bovine erythrocytes and from electric eel with Kis of 36 and 45 μM, respectively.
Targets&IC50	AChE (bovine erythrocytes):Ki:36 μM, AChE (electric eel):Ki:45 μM
Synonyms	Pitophenone hydrochloride, Baralgin Ketone Hydrochloride

Chemical Properties

Molecular Weight	403.9
Formula	C₂₂H₂₆ClNO₄
Cas No.	1248-42-6
Smiles	Cl.COC(=O)c1ccccc1C(=O)c1ccc(OCCN2CCCCC2)cc1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (111.41 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2.48 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4759 mL	12.3793 mL	24.7586 mL	123.7930 mL
5 mM	0.4952 mL	2.4759 mL	4.9517 mL	24.7586 mL
10 mM	0.2476 mL	1.2379 mL	2.4759 mL	12.3793 mL
20 mM	0.1238 mL	0.6190 mL	1.2379 mL	6.1897 mL
50 mM	0.0495 mL	0.2476 mL	0.4952 mL	2.4759 mL
100 mM	0.0248 mL	0.1238 mL	0.2476 mL	1.2379 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc