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Anti-IL-10 Antibody (3K295)
😃Good
Catalog No. TMAH-00606
Alias TGIF, MGC126451, MGC126450, Interleukin-10, IL10A, IL-10, GVHDS, CSIF, B-TCGF
Anti-IL-10 Antibody (3K295) is an antibody targeting IL-10. Anti-IL-10 Antibody (3K295) can be used in ELISA.
Anti-IL-10 Antibody (3K295)
Anti-IL-10 Antibody (3K295)
😃Good
Catalog No. TMAH-00606Alias TGIF, MGC126451, MGC126450, Interleukin-10, IL10A, IL-10, GVHDS, CSIF, B-TCGF
Anti-IL-10 Antibody (3K295) is an antibody targeting IL-10. Anti-IL-10 Antibody (3K295) can be used in ELISA.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $208 | 7-10 days | 7-10 days | |
| 100 μL | $348 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-IL-10 Antibody (3K295) is an antibody targeting IL-10. Anti-IL-10 Antibody (3K295) can be used in ELISA. |
| Synonyms | TGIF, MGC126451, MGC126450, Interleukin-10, IL10A, IL-10, GVHDS, CSIF, B-TCGF |
| Ig Type | Rabbit IgG |
| Clone | 3K295 |
| Reactivity | Human |
| Application | |
| Antibody Type | Monoclonal |
| Subcellular Localization | Secreted. |
| Tissue Specificity | Produced by a variety of cell lines, including T-cells, macrophages, mast cells and other cell types. |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF-alpha. Interferes also with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation. In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling. |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide: Human IL10 |
| Antigen Species | Human |
| Gene Name | IL10 |
| Gene ID | |
| Uniprot ID | |
| Biology Area | Immunology |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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