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2'-Hydroxy-2-methoxychalcone

Name: 2'-Hydroxy-2-methoxychalcone
Brand: TargetMol
SKU: T7432
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7432Cas No. 42220-77-9

Alias 2'-Hydroxy-2-methoxychalcone

2'-Hydroxy-2-methoxychalcone is a synthetic chalcone with antibacterial activity.

2'-Hydroxy-2-methoxychalcone

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Purity: 99.36%

Catalog No. T7432Alias 2'-Hydroxy-2-methoxychalconeCas No. 42220-77-9

2'-Hydroxy-2-methoxychalcone is a synthetic chalcone with antibacterial activity.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$30	In Stock	In Stock
5 mg	$43	In Stock	In Stock
10 mg	$68	In Stock	In Stock
25 mg	$139	In Stock	In Stock
50 mg	$208	In Stock	In Stock
100 mg	$302	In Stock	In Stock
200 mg	$417	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$47	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.36%

Appearance:Solid

Color:Yellow

Resource Download

COA LCMS HNMR

Product Introduction

2'-Hydroxy-2-methoxychalcone AI Summary

2'-Hydroxy-2-methoxychalcone exhibits a wide range of bioactivities, prominently including antioxidant and cytotoxic properties. It is effective in scavenging various radicals such as DPPH, superoxide anion, and hydroxyl radicals, with the highest activity seen in hydroxyl radical scavenging. It also inhibits lipid peroxidation and soybean 5-lipoxygenase, suggesting potential anti-inflammatory effects. Additionally, 2'-Hydroxy-2-methoxychalcone acts as an inverse agonist at the human cytomegalovirus US28 receptor in HEK293T cells, activating the MAPK signaling pathway with 67.0% efficacy at 10 µM and displaying EC50 values of 1445.44 nM and 1400.0 nM. The compound demonstrates cytotoxicity, particularly against CHO cells with an IC50 of 25500 nM and inhibits cell viability in human TZM-bl and CHO cells. It also shows antagonist activity at the androgen receptor in human LNCAP cells, with an IC50 value of 3500.0 nM, and inhibits PMA-induced ROS/RNS generation in human neutrophils, reducing ROS/RNS by 50% at 6.3 µM. Lastly, 2'-Hydroxy-2-methoxychalcone inhibits the growth of cisplatin-resistant human A2780cis cells with GI50 values around 11,748,975.55 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	2'-Hydroxy-2-methoxychalcone is a synthetic chalcone with antibacterial activity.
Synonyms	2'-Hydroxy-2-methoxychalcone

Chemical Properties

Molecular Weight	254.28
Formula	C₁₆H₁₄O₃
Cas No.	42220-77-9
Smiles	COc1ccccc1C=CC(=O)c1ccccc1O
Relative Density.	1.197g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (196.63 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.9327 mL	19.6634 mL	39.3267 mL	196.6336 mL
5 mM	0.7865 mL	3.9327 mL	7.8653 mL	39.3267 mL
10 mM	0.3933 mL	1.9663 mL	3.9327 mL	19.6634 mL
20 mM	0.1966 mL	0.9832 mL	1.9663 mL	9.8317 mL
50 mM	0.0787 mL	0.3933 mL	0.7865 mL	3.9327 mL
100 mM	0.0393 mL	0.1966 mL	0.3933 mL	1.9663 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc