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Norisoboldine

Name: Norisoboldine
Brand: TargetMol
SKU: T5S1895
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5S1895Cas No. 23599-69-1

Alias Laurelliptine, (+)-Laurelliptine

1. Norisoboldine ((+)-Laurelliptine) might be a potential therapeutic agent for rheumatoid arthritis, and it functions through protecting joint destruction as well as regulating the abnormal immune responses. 2. Norisoboldine inhibits the macrophage activation and the resultant production of pro-inflammatory cytokines via down-regulating the activation of MAPKs signaling pathways rather than NF-κB.

Norisoboldine

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Purity: 99.7%

Catalog No. T5S1895Alias Laurelliptine, (+)-LaurelliptineCas No. 23599-69-1

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$30	In Stock	In Stock
5 mg	$60	In Stock	In Stock
10 mg	$85	In Stock	In Stock
25 mg	$138	In Stock	In Stock
50 mg	$197	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.7%

Appearance:Solid

Color:Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Norisoboldine AI Summary

Norisoboldine induces Treg cell differentiation in both naive T-cells and in a DSS-induced ulcerative colitis mouse model. In naive T-cells, it increases the number of Treg cells in a dose-dependent manner, as demonstrated by flow cytometry analysis. In the ulcerative colitis mouse model, the administration of the compound results in an increase in the number of Treg cells in colonic lamina propria, mesenteric lymph nodes, and spleens. These findings suggest that Norisoboldine has bioactivity in promoting Treg cell differentiation and may provide therapeutic benefits for immune-related conditions such as ulcerative colitis..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Synonyms

Laurelliptine, (+)-Laurelliptine

Chemical Properties

Molecular Weight	313.35
Formula	C₁₈H₁₉NO₄
Cas No.	23599-69-1
Smiles	COc1cc-2c(C[C@@H]3NCCc4cc(OC)c(O)c-2c34)cc1O
Relative Density.	1.313 g/cm3

Storage & Solubility Information

Storage

keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.: Soluble

DMSO: 250 mg/mL (797.83 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.38 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1913 mL	15.9566 mL	31.9132 mL	159.5660 mL
5 mM	0.6383 mL	3.1913 mL	6.3826 mL	31.9132 mL
10 mM	0.3191 mL	1.5957 mL	3.1913 mL	15.9566 mL
20 mM	0.1596 mL	0.7978 mL	1.5957 mL	7.9783 mL
50 mM	0.0638 mL	0.3191 mL	0.6383 mL	3.1913 mL
100 mM	0.0319 mL	0.1596 mL	0.3191 mL	1.5957 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc