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Tiamulin
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Catalog No. T8065Cas No. 55297-95-5
Alias Thiamutilin
Tiamulin (Thiamutilin) is a semisynthetic pleuromutilin antibiotic
Tiamulin
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Purity: 99.85%
Catalog No. T8065Alias ThiamutilinCas No. 55297-95-5
Tiamulin (Thiamutilin) is a semisynthetic pleuromutilin antibiotic
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 200 mg | $44 | - | In Stock | |
| 500 mg | $75 | - | In Stock | |
| 1 g | $107 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $30 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.85%
Appearance:Oil
Color:Transparent
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Product Introduction
Tiamulin AI Summary
Tiamulin exhibits significant antibacterial activity against a broad spectrum of bacteria, including methicillin-sensitive and methicillin-resistant strains of Staphylococcus aureus, methicillin-resistant Staphylococcus epidermidis, and Escherichia coli. The minimum inhibitory concentration (MIC) values vary widely depending on the bacterial strain and specific genetic mutations, with values ranging from as low as 0.06 ug/mL to greater than 128.0 ug/mL. The compound shows potent activity particularly against methicillin-resistant Staphylococcus aureus (MRSA) with MIC values from 0.5 to 1.0 ug/mL, and demonstrates bactericidal properties with minimum bactericidal concentration (MBC) values from 1.0 to 2.0 ug/mL.
Tiamulin also binds to the 23S rRNA in Escherichia coli, with significant binding affinity evidenced by chemical footprinting analyses at binding sites U2506 and U2585. Additionally, it shows activity against bacterial strains with genetic resistance mechanisms, such as those harboring cfr, fexA, and multiple resistance genes, although its effectiveness is reduced in these cases with higher MIC values.
In vivo studies highlight its efficacy in reducing bacterial loads and improving survival rates in mouse models of MRSA infection. Furthermore, the compound exhibits moderate to strong post-antibiotic effects and efficacy in systemic infection models. The compound also shows P-glycoprotein (P-gp) inhibitory activity, enhancing doxorubicin-induced antitumor effects in cell models.
Overall, Tiamulin demonstrates promising antibacterial properties, particularly against resistant strains of Staphylococcus aureus and could be a potential candidate for further development as a therapeutic agent for bacterial infections..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Tiamulin (Thiamutilin) is a semisynthetic pleuromutilin antibiotic |
| Synonyms | Thiamutilin |
| Molecular Weight | 493.74 |
| Formula | C28H47NO4S |
| Cas No. | 55297-95-5 |
| Smiles | [H][C@@]12C(=O)CC[C@]11CC[C@@H](C)[C@@]2(C)[C@@H](C[C@@](C)(C=C)[C@@H](O)[C@@H]1C)OC(=O)CSCCN(CC)CC |
| Relative Density. | 1.0160 g/cm3 (Estimated) |
| Storage | store at low temperature | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 250 mg/mL (506.34 mM), Sonication is recommended.  Ethanol: 2 mg/mL (4.05 mM), Sonication is recommended. H2O: 11 mg/mL (22.28 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (10.13 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||||||||||||
Ethanol/H2O/DMSO
H2O/DMSO
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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