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magnolin

Name: magnolin
Brand: TargetMol
SKU: T3857
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3857Cas No. 31008-18-1

Alias (+)-Magnolin

Magnolin reduces the renal oxidative stress, suppresses caspase-3 activity, and increases Bcl-2 expression in vivo and in vitro. Magnolin has anti-inflammatory and antioxidative effects.

magnolin

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Purity: 99.77%

Catalog No. T3857Alias (+)-MagnolinCas No. 31008-18-1

Magnolin reduces the renal oxidative stress, suppresses caspase-3 activity, and increases Bcl-2 expression in vivo and in vitro. Magnolin has anti-inflammatory and antioxidative effects.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$33	In Stock	In Stock
10 mg	$59	In Stock	In Stock
25 mg	$105	In Stock	In Stock
50 mg	$152	In Stock	In Stock
100 mg	$223	In Stock	In Stock
200 mg	$329	-	In Stock
1 mL x 10 mM (in DMSO)	$36	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.77%

Color:White

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COA HPLC HNMR

Product Introduction

magnolin AI Summary

magnolin inhibits the production of nitric oxide in LPS-stimulated mouse BV2 cells with an IC50 value of 20500.0 nM, as measured by nitrite accumulation using the Griess reagent method after 20 hours. Additionally, magnolin exhibits inhibitory bioactivity against acetylcholinesterase, with an IC50 value of 903.0 nM and inhibition greater than 90.0% at concentrations ranging from 0.01 to 100 µM. These properties suggest that magnolin may have potential applications in modulating cholinergic neurotransmission pathways and reducing nitric oxide production..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Magnolin reduces the renal oxidative stress, suppresses caspase-3 activity, and increases Bcl-2 expression in vivo and in vitro. Magnolin has anti-inflammatory and antioxidative effects.
Targets&IC50	ERK1:87 nM, ERK2:16.5 nM
Synonyms	(+)-Magnolin

Chemical Properties

Molecular Weight	416.46
Formula	C₂₃H₂₈O₇
Cas No.	31008-18-1
Smiles	COc1ccc(cc1OC)[C@H]1OC[C@H]2[C@@H]1CO[C@@H]2c1cc(OC)c(OC)c(OC)c1
Relative Density.	1.178 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (600.3 mM), Sonication is recommended.

H2O: ＜1 mg/mL (insoluble)

Chloroform, Dichloromethane, Ethyl Acetate: Soluble

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.8 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4012 mL	12.0060 mL	24.0119 mL	120.0595 mL
5 mM	0.4802 mL	2.4012 mL	4.8024 mL	24.0119 mL
10 mM	0.2401 mL	1.2006 mL	2.4012 mL	12.0060 mL
20 mM	0.1201 mL	0.6003 mL	1.2006 mL	6.0030 mL
50 mM	0.0480 mL	0.2401 mL	0.4802 mL	2.4012 mL
100 mM	0.0240 mL	0.1201 mL	0.2401 mL	1.2006 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc