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Dalbavancin hydrochloride

Name: Dalbavancin hydrochloride
Brand: TargetMol
SKU: T75253
Price: 52 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: MDL-63397 hydrochloride, MDL63397 hydrochloride, MDL 63397 hydrochloride, BI-397 hydrochloride, BI397 hydrochloride, BI 397 hydrochloride) Copy Product Info

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Synonyms: MDL-63397 hydrochloride, MDL63397 hydrochloride, MDL 63397 hydrochloride, BI-397 hydrochloride, BI397 hydrochloride, BI 397 hydrochloride

Catalog No. T75253 Copy Product Info

Purity: 98.02%

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Dalbavancin hydrochloride (MDL-63397 hydrochloride) is a semi-synthetic lipopeptide antibiotic that inhibits bacterial cell wall synthesis and exhibits potent bactericidal activity against Gram-positive bacteria. The MIC90 values of dalbavancin hydrochloride against Staphylococcus aureus and Bacillus anthracis are 0.06 μg/mL and 0.25 μg/mL, respectively.

Cas No. 2227366-51-8

Pack Size	Price	USA Stock	Global Stock
1 mg	$52	-	In Stock
5 mg	$123	-	In Stock
10 mg	$197	-	In Stock
25 mg	$392	-	In Stock
50 mg	$588	-	In Stock
100 mg	$839	-	In Stock
1 mL x 10 mM (in DMSO)	$358	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:98.02%

Appearance:Solid

Color:White

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COA LCMS

Product Introduction

Bioactivity

Description	Dalbavancin hydrochloride (MDL-63397 hydrochloride) is a semi-synthetic lipopeptide antibiotic that inhibits bacterial cell wall synthesis and exhibits potent bactericidal activity against Gram-positive bacteria. The MIC90 values of dalbavancin hydrochloride against Staphylococcus aureus and Bacillus anthracis are 0.06 μg/mL and 0.25 μg/mL, respectively.
In vitro	Methods: Thirty strains of B. anthracis were selected and incubated with Dalbavancin hydrochloride at concentrations ranging from 0.03 to 64 μg/ml for 18–24 hours; the MIC was determined using the microdilution broth method. Results: The MIC range for Dalbavancin hydrochloride was ≤0.03–0.5 μg/ml; MIC₅₀ = 0.06 μg/ml; MIC₉₀ = 0.25 μg/ml.[1]
In vivo	Methods: To investigate the efficacy of Dalbavancin hydrochloride, female BALB/c mice were exposed to an aerosol challenge with Bacillus anthracis strain Ames. Twenty-four hours after infection, intraperitoneal injections of Dalbavancin hydrochloride (15–120 mg/kg) were administered daily for 14 days, and mouse survival rates were assessed 42 days later. Results: The survival rate of mice in the Dalbavancin hydrochloride treatment group was 80–100%. [1] Methods: To investigate the pharmacokinetics of repeated doses of Dalbavancin hydrochloride, SD rats were used. Dalbavancin hydrochloride (40 mg/kg) was administered intravenously once daily for 28 consecutive days. Blood samples were collected at the same time points as for the single-dose study following the final administration. Results: Compared with Day 1, the AUC(0–∞) on Day 28 increased 2–6-fold, indicating accumulation of Dalbavancin hydrochloride.
Synonyms	MDL-63397 hydrochloride, MDL63397 hydrochloride, MDL 63397 hydrochloride, BI-397 hydrochloride, BI397 hydrochloride, BI 397 hydrochloride

Chemical Properties

Molecular Weight	1853.15
Formula	C₈₈H₁₀₁Cl₃N₁₀O₂₈
Cas No.	2227366-51-8
Smiles	O[C@H]([C@@H](OC1=C(C([C@@]([H])(C(NCCCN(C)C)=O)NC([C@]([H])([C@H](O)C2=CC=C(C(Cl)=C2)O3)N4)=O)=CC(O)=C1)C5=CC([C@@]([H])(NC([C@]6([H])NC([C@]([H])(C7=C(Cl)C(O)=CC(OC8=C(O)C=CC([C@H]9NC)=C8)=C7)NC([C@@]([H])(CC(C=C%10)=CC=C%10OC%11=CC6=CC3=C%11O[C@@H]([C@@H]%12NC(CCCCCCCCC(C)C)=O)O[C@@H]([C@H]([C@@H]%12O)O)C(O)=O)NC9=O)=O)=O)=O)C4=O)=CC=C5O)O[C@@H]%13CO)[C@H]([C@@H]%13O)O.Cl

Storage & Solubility Information

Storage

Keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 200 mg/mL (107.92 mM), Sonication is recommended.

H2O: 40 mg/mL (21.58 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	0.5396 mL	2.6981 mL	5.3962 mL	26.9811 mL
5 mM	0.1079 mL	0.5396 mL	1.0792 mL	5.3962 mL
10 mM	0.0540 mL	0.2698 mL	0.5396 mL	2.6981 mL
20 mM	0.0270 mL	0.1349 mL	0.2698 mL	1.3491 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0108 mL	0.0540 mL	0.1079 mL	0.5396 mL
100 mM	0.0054 mL	0.0270 mL	0.0540 mL	0.2698 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Related Tags: Dalbavancin hydrochloride chemical structure | Dalbavancin hydrochloride in vivo | Dalbavancin hydrochloride in vitro | Dalbavancin hydrochloride formula | Dalbavancin hydrochloride molecular weight