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Anti-p53R2 Antibody (4V66)
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Catalog No. TMAY-02507
Alias ribonucleotide reductase M2 B (TP53 inducible), P53R2, MTDPS8B, MTDPS8A
Anti-p53R2 Antibody (4V66) is a Mouse antibody targeting p53R2. Anti-p53R2 Antibody (4V66) can be used in WB,ELISA,ELISA(Det).
Anti-p53R2 Antibody (4V66)
Anti-p53R2 Antibody (4V66)
😃Good
Catalog No. TMAY-02507Alias ribonucleotide reductase M2 B (TP53 inducible), P53R2, MTDPS8B, MTDPS8A
Anti-p53R2 Antibody (4V66) is a Mouse antibody targeting p53R2. Anti-p53R2 Antibody (4V66) can be used in WB,ELISA,ELISA(Det).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 20 μL | $68 | 7-10 days | |
| 100 μL | $199 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-p53R2 Antibody (4V66) is a Mouse antibody targeting p53R2. Anti-p53R2 Antibody (4V66) can be used in WB,ELISA,ELISA(Det). |
| Alias | ribonucleotide reductase M2 B (TP53 inducible), P53R2, MTDPS8B, MTDPS8A |
| Ig Type | Monoclonal Mouse IgG1 |
| Clone | 4V66 |
| Reactivity | Human |
| Verified Activity | 1. Anti-RRM2B mouse monoclonal antibody at 1:500 dilution. -Lane A: MCF7 Whole Cell lysate. -Lysates/proteins at 30 μg per lane. -Secondary -Goat Anti-Mouse IgG H&L (Dylight800) at 1/15000 dilution. -Developed using the Odyssey technique. -Performed under reducing conditions. -Predicted band size:40 kDa. -Observed band size:40 kDa. 2. Anti-RRM2B mouse monoclonal antibody at 1:500 dilution. -Lane A: 293T Whole Cell Lysate. -Lane B: RRM2B knockout 293T Whole Cell lysate. -Lysates/proteins at 30 μg per lane. -Secondary -Goat Anti-Mouse IgG (H+L)/HRP at 1/10000 dilution. -Developed using the ECL technique. -Performed under reducing conditions. -Predicted band size:40 kDa. -Observed band size:39 kDa |
| Application | WB,ELISA,ELISA(Det) |
| Recommended Dose | WB: 1:500-1:2000; ELISA: 1:5000-1:10000; ELISA(Det): 1:5000-1:50000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human RRM2B / P53R2 (rh RRM2B / P53R2; TMPY-02527; Q7LG56-1; Met 1-Phe 351). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS with 0.02% Tween 80, pH 7.0 |
| Research Background | Ribonucleoside reductase subunit M2B, also known as RRM2B or p53R2, is an enzyme belonging to the iron-dependent ribonucleotide reductase (RNR) enzyme family which is essential for DNA synthesis. Ribonucleotide reductase (RNR) is an enzyme that catalyzes the formation of deoxyribonucleotides from ribonucleotides and plays a critical role in regulating the total rate of DNA synthesis so that DNA to cell mass is maintained at a constant ratio during cell division and DNA repair. RRM2B is a phosphorylated protein. It is hypothesized that RRM2B activity can be regulated at the posttranslational level in response to DNA damage. RRM2B has previously been shown to be essential for the maintenance of mtDNA copy number and its candidacy for tumor suppression has been evaluated in several mutational analyses of different cancer types. However, the contribution of RRM2B to the DNA damage response has been questioned because its transcriptional induction upon DNA damage is not rapid enough for prompt DNA repair. Instead, ATM-mediated phosphorylation has been suggested to regulate the DNA repair activity of RRM2B posttranslationally. Besides, a defect in RRM2B can induce a mild muscle disease of adult onset through disturbance of mitochondrial homeostasis but that this defect does not appear to be oncogenic. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Human RRM2B / P53R2 protein (TMPY-02527) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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