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Pyridostigmine bromide

Name: Pyridostigmine bromide
Brand: TargetMol
SKU: T0780
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0780Cas No. 101-26-8

Alias Mestinon

Pyridostigmine bromide (Mestinon) is a cholinesterase inhibitor with a slightly longer duration of action than NEOSTIGMINE. It is used in the treatment of myasthenia gravis and to reverse the actions of muscle relaxants.

Pyridostigmine bromide

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Purity: 99.98%

Catalog No. T0780Alias MestinonCas No. 101-26-8

Pack Size	Price	USA Warehouse	Global Warehouse
200 mg	$30	In Stock	In Stock
500 mg	$45	In Stock	In Stock
1 g	$76	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.98%

Color:White

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COA HNMR LCMS

Product Introduction

Pyridostigmine bromide AI Summary

Pyridostigmine bromide exhibits multiple bioactivities, including acute toxicity and enzyme inhibition. It has LD50 values of 2.6 mg/kg in mice and 3.3 mg/kg in rats, showcasing its high toxicity. The compound demonstrates protective effects against soman poisoning in mice at a dose of 10 mg/kg with a protective ratio of 3.1. It acts as an acetylcholinesterase (AChE) inhibitor with an IC50 value of 360.0 nM for human RBC AChE and 900.0 nM for human plasma butyrylcholinesterase (BChE), with a selectivity ratio of 2.5. Furthermore, Pyridostigmine bromide shows moderate antiviral activity against SARS-CoV-2 and antifungal activity against Candida albicans, although it exhibits weak inhibition of the BSEP transporter and marginal antibacterial activity. Additionally, it affects Schwann cell viability and induces DNA re-replication in normal breast cells. Pyridostigmine bromide also inhibits the entry of the Ebola virus and shows interactions with chromodomains and histone methyltransferases, suggesting its diverse bioactive properties..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Pyridostigmine bromide (Mestinon) is a cholinesterase inhibitor with a slightly longer duration of action than NEOSTIGMINE. It is used in the treatment of myasthenia gravis and to reverse the actions of muscle relaxants.
Synonyms	Mestinon

Chemical Properties

Molecular Weight	261.12
Formula	C₉H₁₃BrN₂O₂
Cas No.	101-26-8
Smiles	[Br-].CN(C)C(=O)Oc1c[n+](C)ccc1
Relative Density.	0.9613 g/cm3 (20°C)

Storage & Solubility Information

Storage

keep away from moisture | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 48 mg/mL (183.82 mM), Sonication is recommended.

Ethanol: 49 mg/mL (187.65 mM), Sonication is recommended.

DMSO: 50 mg/mL (191.48 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.66 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.8297 mL	19.1483 mL	38.2966 mL	191.4828 mL
5 mM	0.7659 mL	3.8297 mL	7.6593 mL	38.2966 mL
10 mM	0.3830 mL	1.9148 mL	3.8297 mL	19.1483 mL
20 mM	0.1915 mL	0.9574 mL	1.9148 mL	9.5741 mL
50 mM	0.0766 mL	0.3830 mL	0.7659 mL	3.8297 mL
100 mM	0.0383 mL	0.1915 mL	0.3830 mL	1.9148 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc