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Oleandrin

Name: Oleandrin
Brand: TargetMol
SKU: T5S0890
Price: 78 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: Neriostene, Folinerin, Foliandrin) Copy Product Info

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Synonyms: Neriostene, Folinerin, Foliandrin

Catalog No. T5S0890 Copy Product Info

Purity: 99.97%

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1. Oleandrin (Folinerin), the principal cardiac glycoside component of PBI-524, can quantitatively account for regulation of BDNF at both the protein and transcriptional levels. 2. Oleandrin are known to inhibit the Na, K-ATPase pump, resulting in a consequent increase in calcium influx in heart muscle. 3. Oleandrin has stronger anti-proliferative activity in undifferentiated CaCO-2 cells (IC50, 8.25 nM) , causes an autophagic cell death and altered ERK phosphorylation in undifferentiated.

Cas No. 465-16-7

Pack Size	Price	USA Stock	Global Stock
1 mg	$78	In Stock	In Stock
5 mg	$189	In Stock	In Stock
10 mg	$278	In Stock	In Stock
25 mg	$562	In Stock	In Stock
50 mg	$828	In Stock	In Stock
100 mg	$1,180	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$237	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.97%

Color:White

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COA LCMS HNMR

Product Introduction

Oleandrin AI Summary

Oleandrin exhibits a range of bioactivities, including notable cytotoxicity and antiviral effects. It inhibits the N-terminal FLAG-tagged Notch1 protein in mouse cells, reducing NICD expression with an IC50 of 120.0 nM. This compound also demonstrates significant cytotoxicity against various human cell lines: human HPBALL cells with an IC50 of 14.0 nM, HEK293 cells with an IC50 of 28.0 nM, CEM cells with an IC50 of 19.0 nM, MCF7 cells with an IC50 of 33.0 nM, HeLa cells with an IC50 of 62.0 nM, and BJ cells with an IC50 of 26.0 nM after 72 hours. Additionally, Oleandrin shows antiviral activity against SARS-CoV-2 by inhibiting cytotoxicity in Caco-2 cells (49.78% inhibition at 10 µM after 48 hours), and inhibits the SARS-CoV-2 3CL-Pro protease by 11.04% at 20 µM. It also has demonstrated inhibitory effects on porcine kidney Na+/K+-ATPase, reducing activity by 49.0% when preincubated at 50 µM for 2 minutes. However, its binding affinity towards various receptors in vitro indicates it does not exhibit significant bioactivity as an inhibitor or activator, with AC50 values greater than 30000.0 nM. Furthermore, it has shown inhibitory activity against human HDAC6 enzyme, with inhibition rates of 39.77% using a commercial peptide substrate and 3.43% using a custom peptide substrate..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	1. Oleandrin (Folinerin), the principal cardiac glycoside component of PBI-524, can quantitatively account for regulation of BDNF at both the protein and transcriptional levels. 2. Oleandrin are known to inhibit the Na, K-ATPase pump, resulting in a consequent increase in calcium influx in heart muscle. 3. Oleandrin has stronger anti-proliferative activity in undifferentiated CaCO-2 cells (IC50, 8.25 nM) , causes an autophagic cell death and altered ERK phosphorylation in undifferentiated.
Targets & IC50	Na+, K+-ATPase:620 nM (IC50)
Synonyms	Neriostene, Folinerin, Foliandrin

Chemical Properties

Molecular Weight	576.72
Formula	C₃₂H₄₈O₉
Cas No.	465-16-7
Smiles	[H][C@]12CC[C@]3([H])[C@]([H])(CC[C@]4(C)[C@H]([C@H](C[C@]34O)OC(C)=O)C3=CC(=O)OC3)[C@@]1(C)CC[C@@H](C2)O[C@H]1C[C@H](OC)[C@@H](O)[C@H](C)O1
Relative Density.	1.26 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: Soluble

Pyridine, Methanol, etc.: Soluble

DMSO: 150 mg/mL (260.09 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Saline: < 10 mg/mL (17.34 mM), Lower concentrations may be soluble, but exact solubility limit is unknown.

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 10 mg/mL (17.34 mM), Solution.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7339 mL	8.6697 mL	17.3394 mL	86.6972 mL
5 mM	0.3468 mL	1.7339 mL	3.4679 mL	17.3394 mL
10 mM	0.1734 mL	0.8670 mL	1.7339 mL	8.6697 mL
20 mM	0.0867 mL	0.4335 mL	0.8670 mL	4.3349 mL
50 mM	0.0347 mL	0.1734 mL	0.3468 mL	1.7339 mL
100 mM	0.0173 mL	0.0867 mL	0.1734 mL	0.8670 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc