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Oleandrin

Name: Oleandrin
Brand: TargetMol
SKU: T5S0890
Price: 78 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T5S0890Cas No. 465-16-7

Alias Neriostene, Folinerin, Foliandrin

1. Oleandrin (Folinerin), the principal cardiac glycoside component of PBI-524, can quantitatively account for regulation of BDNF at both the protein and transcriptional levels. 2. Oleandrin are known to inhibit the Na, K-ATPase pump, resulting in a consequent increase in calcium influx in heart muscle. 3. Oleandrin has stronger anti-proliferative activity in undifferentiated CaCO-2 cells (IC50, 8.25 nM) , causes an autophagic cell death and altered ERK phosphorylation in undifferentiated.

Oleandrin

🥰Excellent

Purity: 99.94%

Catalog No. T5S0890Alias Neriostene, Folinerin, FoliandrinCas No. 465-16-7

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$78	In Stock	In Stock
5 mg	$189	In Stock	In Stock
10 mg	$313	In Stock	In Stock
25 mg	$658	In Stock	In Stock
50 mg	$1,050	In Stock	In Stock
100 mg	$1,430	In Stock	In Stock
200 mg	$1,930	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$248	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.94%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	1. Oleandrin (Folinerin), the principal cardiac glycoside component of PBI-524, can quantitatively account for regulation of BDNF at both the protein and transcriptional levels. 2. Oleandrin are known to inhibit the Na, K-ATPase pump, resulting in a consequent increase in calcium influx in heart muscle. 3. Oleandrin has stronger anti-proliferative activity in undifferentiated CaCO-2 cells (IC50, 8.25 nM) , causes an autophagic cell death and altered ERK phosphorylation in undifferentiated.
Targets&IC50	Na+, K+-ATPase:620 nM (IC50)
Synonyms	Neriostene, Folinerin, Foliandrin

Chemical Properties

Molecular Weight	576.72
Formula	C₃₂H₄₈O₉
Cas No.	465-16-7
Smiles	[H][C@]12CC[C@]3([H])[C@]([H])(CC[C@]4(C)[C@H]([C@H](C[C@]34O)OC(C)=O)C3=CC(=O)OC3)[C@@]1(C)CC[C@@H](C2)O[C@H]1C[C@H](OC)[C@@H](O)[C@H](C)O1
Relative Density.	1.26 g/cm3
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: Soluble

Pyridine, Methanol, etc.: Soluble

DMSO: 60 mg/mL (104.04 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.47 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7339 mL	8.6697 mL	17.3394 mL	86.6972 mL
5 mM	0.3468 mL	1.7339 mL	3.4679 mL	17.3394 mL
10 mM	0.1734 mL	0.8670 mL	1.7339 mL	8.6697 mL
20 mM	0.0867 mL	0.4335 mL	0.8670 mL	4.3349 mL
50 mM	0.0347 mL	0.1734 mL	0.3468 mL	1.7339 mL
100 mM	0.0173 mL	0.0867 mL	0.1734 mL	0.8670 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc