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Zosurabalpin
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Catalog No. T74598Cas No. 2379336-76-0
Alias RG6006, RG 6006, Abx MCP
Zosurabalpin (Abx MCP) is a macrolide antibiotic effective against drug-resistant Gram-negative bacteria, such as carbapenem-resistant Acinetobacter baumannii (CRAB), by binding to and inhibiting the protein machinery complex LptB2FGC involved in the transport of outer membrane lipopolysaccharides.
Zosurabalpin
😃Good
Catalog No. T74598Alias RG6006, RG 6006, Abx MCPCas No. 2379336-76-0
Zosurabalpin (Abx MCP) is a macrolide antibiotic effective against drug-resistant Gram-negative bacteria, such as carbapenem-resistant Acinetobacter baumannii (CRAB), by binding to and inhibiting the protein machinery complex LptB2FGC involved in the transport of outer membrane lipopolysaccharides.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | Inquiry | Backorder | |
| 50 mg | Inquiry | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Zosurabalpin (Abx MCP) is a macrolide antibiotic effective against drug-resistant Gram-negative bacteria, such as carbapenem-resistant Acinetobacter baumannii (CRAB), by binding to and inhibiting the protein machinery complex LptB2FGC involved in the transport of outer membrane lipopolysaccharides. |
| In vitro | Method: A. baumannii isolates were treated with Zosurabalpin at concentrations of 0.01, 0.1, 1, and 10 μM and incubated for 24 hours to assess its effect on lipopolysaccharide (LPS) extraction. Result: Zosurabalpin reduced LPS extraction from A. baumannii in a concentration-dependent manner. [3] |
| Synonyms | RG6006, RG 6006, Abx MCP |
| Molecular Weight | 790.97 |
| Formula | C43H50N8O5S |
| Cas No. | 2379336-76-0 |
| Smiles | O=C1NCC2=C(C=CC=C2SC=3C(CN[C@@H](CCCN)C(=O)N[C@@H](CCCCN)C(=O)N(C)[C@H]1CC=4C=5C(NC4)=CC=CC5)=CC=CN3)C6=CC=C(C(O)=O)C=C6 |
| Color | White |
| Appearance | Solid |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||
| Solubility Information | DMSO: 3 mg/mL (3.79 mM), when pH is adjusted to 7 with 1M HCL. Sonication is recommended. | ||||||||||
Solution Preparation Table | |||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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