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Mebrofenin

Name: Mebrofenin
Brand: TargetMol
SKU: T8364
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8364Cas No. 78266-06-5

Alias SQ 26962

Mebrofenin (SQ 26962) is available as a ready to use the kit for radio-labeling with Tc-99m.Technetium Tc 99m Mebrofenin is a diagnostic radiopharmaceutical composed of diisopropyl-iminodiacetic acid (DISIDA) attached to a technetium-99m ion.

Mebrofenin

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Purity: 99.88%

Catalog No. T8364Alias SQ 26962Cas No. 78266-06-5

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$40	In Stock	In Stock
25 mg	$73	In Stock	In Stock
50 mg	$106	In Stock	In Stock
100 mg	$153	In Stock	In Stock
200 mg	$228	-	In Stock
1 mL x 10 mM (in DMSO)	$39	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.88%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Mebrofenin AI Summary

Mebrofenin is a multifaceted bioactive molecule, known for its inhibitory properties against various targets. It inhibits Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) with a potency of 100,000 nM and the malarial parasite plastid with a delayed death potency of 3,380.8 nM. It also targets Glutaminase (GLS) with a potency of 17,782.8 nM and human tyrosyl-DNA phosphodiesterase 1 (TDP1) in cells in the presence of CPT with a potency of 33,498.3 nM. Furthermore, it blocks the entry of Ebola Virus in Screen 2 green channel with an AC50 of 19,952.6 nM (or 19.95 µM). Moreover, Mebrofenin demonstrates antiviral activity against SARS-CoV-2, showing 35.51% inhibition of the SARS-CoV-2 3CL-Pro protease at 20 µM in a FRET assay using a peptide substrate. It also inhibits virus-induced cytotoxicity in VERO-6 cells with an inhibition rate of 0.52% at 10 µM after 48 hours as per high content imaging analysis. Despite showing binding affinity towards a range of receptors including human DRD1, KCNH2, and others, the compound does not exhibit significant agonist or antagonist activities nor inhibition at tested concentrations, with AC50 values for all these assays exceeding 30,000 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Mebrofenin (SQ 26962) is available as a ready to use the kit for radio-labeling with Tc-99m.Technetium Tc 99m Mebrofenin is a diagnostic radiopharmaceutical composed of diisopropyl-iminodiacetic acid (DISIDA) attached to a technetium-99m ion.
Synonyms	SQ 26962

Chemical Properties

Molecular Weight	387.23
Formula	C₁₅H₁₉BrN₂O₅
Cas No.	78266-06-5
Smiles	Cc1cc(C)c(NC(=O)CN(CC(O)=O)CC(O)=O)c(C)c1Br
Relative Density.	1.5766 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 250 mg/mL (645.61 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (8.52 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5824 mL	12.9122 mL	25.8244 mL	129.1222 mL
5 mM	0.5165 mL	2.5824 mL	5.1649 mL	25.8244 mL
10 mM	0.2582 mL	1.2912 mL	2.5824 mL	12.9122 mL
20 mM	0.1291 mL	0.6456 mL	1.2912 mL	6.4561 mL
50 mM	0.0516 mL	0.2582 mL	0.5165 mL	2.5824 mL
100 mM	0.0258 mL	0.1291 mL	0.2582 mL	1.2912 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc