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DPP-IV-IN-2

Name: DPP-IV-IN-2
Brand: TargetMol
SKU: T11526
Price: 85 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11526Cas No. 136259-18-2

Alias H-Lys(4-nitro-Z)-pyrrolidide

DPP-IV-IN-2 (H-Lys(4-nitro-Z)-pyrrolidide) is an inhibitor of both DP8/9 and dipeptidyl peptidase IV (IC50s: 0.1 and 0.95 μM).

DPP-IV-IN-2

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Purity: 99.08%

Catalog No. T11526Alias H-Lys(4-nitro-Z)-pyrrolidideCas No. 136259-18-2

DPP-IV-IN-2 (H-Lys(4-nitro-Z)-pyrrolidide) is an inhibitor of both DP8/9 and dipeptidyl peptidase IV (IC50s: 0.1 and 0.95 μM).

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$34	In Stock	In Stock
25 mg	$54	In Stock	In Stock
50 mg	Preferential	In Stock	-
1 mL x 10 mM (in DMSO)	$85	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.08%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

DPP-IV-IN-2 AI Summary

DPP-IV-IN-2 inhibits DPP8 with an IC50 of 147.0 nM and DPP9 with an IC50 of 168.0 nM, and demonstrates antiproliferative activity against T cells with an IC50 of 839.0 nM. Additionally, it inhibits the SARS-CoV-2 3CL-Pro protease by 1.21% at a concentration of 20 µM. In antiviral assays, DPP-IV-IN-2 inhibits SARS-CoV-2 induced cytotoxicity in VERO-6 cells at a 10 µM concentration after 48 hours of exposure to 0.01 MOI of the virus, resulting in an inhibition rate of 0.91%, as determined by high content imaging..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	DPP-IV-IN-2 (H-Lys(4-nitro-Z)-pyrrolidide) is an inhibitor of both DP8/9 and dipeptidyl peptidase IV (IC50s: 0.1 and 0.95 μM).
Targets&IC50	DP8/9:0.95 μM , DPIV:0.1 μM
Synonyms	H-Lys(4-nitro-Z)-pyrrolidide

Chemical Properties

Molecular Weight	378.42
Formula	C₁₈H₂₆N₄O₅
Cas No.	136259-18-2
Smiles	N[C@@H](CCCCNC(=O)OCc1ccc(cc1)[N+]([O-])=O)C(=O)N1CCCC1
Relative Density.	1.265 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (264.26 mM), Sonication and heating are recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (13.21 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6426 mL	13.2128 mL	26.4257 mL	132.1283 mL
5 mM	0.5285 mL	2.6426 mL	5.2851 mL	26.4257 mL
10 mM	0.2643 mL	1.3213 mL	2.6426 mL	13.2128 mL
20 mM	0.1321 mL	0.6606 mL	1.3213 mL	6.6064 mL
50 mM	0.0529 mL	0.2643 mL	0.5285 mL	2.6426 mL
100 mM	0.0264 mL	0.1321 mL	0.2643 mL	1.3213 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc