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VU0420373
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Catalog No. T60384Cas No. 38376-29-3
VU0420373 is a potent activator of the heme sensor system (HssRS), demonstrating an EC50 of 10.7 μM and a pEC50 of 4.97. It induces heme biosynthesis and exhibits toxicity towards fermenting S. aureus [1].
VU0420373
😃Good
Catalog No. T60384Cas No. 38376-29-3
VU0420373 is a potent activator of the heme sensor system (HssRS), demonstrating an EC50 of 10.7 μM and a pEC50 of 4.97. It induces heme biosynthesis and exhibits toxicity towards fermenting S. aureus [1].
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | Inquiry | 6-8 weeks | 6-8 weeks | |
| 50 mg | Inquiry | 6-8 weeks | 6-8 weeks | |
| 100 mg | Inquiry | 6-8 weeks | 6-8 weeks |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
| Description | VU0420373 is a potent activator of the heme sensor system (HssRS), demonstrating an EC50 of 10.7 μM and a pEC50 of 4.97. It induces heme biosynthesis and exhibits toxicity towards fermenting S. aureus [1]. |
| In vitro | VU0420373 (compound 2e) exhibits an IC50 of >60 μM for both Newman aerobic and Newman anaerobic conditions. Additionally, at a concentration of 40 μM and over exposure periods of 2, 4, 6, and 8 hours, it can pre-adapt Staphylococcus aureus to withstand toxic levels of heme (20 μM). |
| Molecular Weight | 254.26 |
| Formula | C15H11FN2O |
| Cas No. | 38376-29-3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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