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Anti-ZNF195 Polyclonal Antibody is a Rabbit antibody targeting ZNF195. Anti-ZNF195 Polyclonal Antibody can be used in WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $223 | 7-10 days | 7-10 days | |
| 100 μL | $372 | 7-10 days | 7-10 days | |
| 200 μL | $529 | 7-10 days | 7-10 days |
| Description | Anti-ZNF195 Polyclonal Antibody is a Rabbit antibody targeting ZNF195. Anti-ZNF195 Polyclonal Antibody can be used in WB. |
| Ig Type | IgG |
| Reactivity | Human |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Nuclear |
| Tissue Specificity | Expressed in adult heart, brain, placenta, skeletal muscle and pancreas, and in fetal lung, kidney and brain. There is little expression in adult lung, liver and kidney. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Krüppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. Zinc finger protein 195 (ZNF195), also known as ZNFP104, is a 629 amino acid member of the Krüppel C2H2-type zinc-finger protein family. Localized to the nucleus, ZNF195 is expressed in adult brain, heart, placenta, pancreas and skeletal muscle and in fetal brain, lung and kidney. ZNF195 contains ten C2H2-type zinc fingers and one KRAB domain through which it is thought to be involved in DNA-binding and transcriptional regulation. Three isoforms of ZNF195 exist as a result of alternative splicing events. |
| Immunogen | KLH conjugated synthetic peptide: Human ZNF195 |
| Antigen Species | Human |
| Gene Name | ZNF195 |
| Gene ID | |
| Protein Name | Zinc finger protein 195 |
| Uniprot ID | |
| Function | Zinc finger proteins are an important class of eukaryotic DNA binding proteins. The zinc finger motif contains spatially conserved cysteines and histidines, which bind a zinc ion. The most common zinc finger motif is the C2H2 type, which was first identified in the Drosophila segmentation gene, Kruppel. The human genome has several hundred Kruppel related zinc finger genes. About one third of these human Kruppel type genes also code for a highly conserved region, the Kruppel associated box (KRAB domain), comprising approximately 75 amino acids found at the N terminal end. The zinc finger gene ZNF195 contains an N terminal KRAB domain and 14 tandemly repeated Kruppel type zinc finger motifs at its C terminus. ZNF195 may be involved in transcriptional regulation. It is expressed in adult heart, brain, placenta, skeletal muscle and pancreas, and in foetal lung, kidney and brain. There is little expression in adult lung, liver and kidney. |
| Molecular Weight | Theoretical: 72 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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