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Neosmitilbin

Name: Neosmitilbin
Brand: TargetMol
SKU: TN1975
Price: 172 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN1975Cas No. 54081-47-9

Alias Neoastilbin

Neosmitilbin (Neoastilbin) may have antioxidant and anti-inflammatory activities, it shows potent inhibition of lens aldose reductase.

Neosmitilbin

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Purity: 99.94%

Catalog No. TN1975Alias NeoastilbinCas No. 54081-47-9

Neosmitilbin (Neoastilbin) may have antioxidant and anti-inflammatory activities, it shows potent inhibition of lens aldose reductase.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$40	-	In Stock
5 mg	$106	-	In Stock
10 mg	$172	-	In Stock
25 mg	Preferential	-	In Stock
1 mL x 10 mM (in DMSO)	$128	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.94%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Neosmitilbin (Neoastilbin) may have antioxidant and anti-inflammatory activities, it shows potent inhibition of lens aldose reductase.
In vitro	Phenolic-enriched extract of S. glabra (PEESG) was extracted with 70% ethanol and purified by HP-20 column chromatography. Its antioxidant and anti-inflammatory activities were evaluated by radical scavenging assay, reducing power determination, and lipopolysaccharide (LPS)-induced RAW264.7 cells assays, respectively. PEESG exhibited obviously scavenging capacity for DPPH and ABTS radicals, as well as significant reducing power for ferric ion. Particularly, PEESG (12.5??50 μg/mL) showed a significantly higher efficiency for scavenging ABTS than that of ascorbic acid and no significant difference with ascorbic acid for DPPH scavenging. PEESG also possessed a significant suppression effect on proinflammatory mediators production, such as nitric oxide (NO), tumor necrosis factor- α± (TNF- α± ), and interleukin-6 (IL-6), in LPS-induced RAW264.7 cells. In addition, the main ingredients of PEESG were identified using ultrahigh pressure liquid chromatography coupled to electrospray mass spectrometry (U-HPLC-ESI-MS). Seventeen components, including 5-O-caffeoylshikimic acid, Neoastilbin, astilbin, neoisoastilbin, isoastilbin, engetin and isoengeletin were identified.
Synonyms	Neoastilbin

Chemical Properties

Molecular Weight	450.39
Formula	C₂₁H₂₂O₁₁
Cas No.	54081-47-9
Smiles	C[C@@H]1O[C@@H](O[C@H]2[C@@H](Oc3cc(O)cc(O)c3C2=O)c2ccc(O)c(O)c2)[C@H](O)[C@H](O)[C@H]1O
Relative Density.	1.74 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (122.12 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2203 mL	11.1015 mL	22.2030 mL	111.0149 mL
5 mM	0.4441 mL	2.2203 mL	4.4406 mL	22.2030 mL
10 mM	0.2220 mL	1.1101 mL	2.2203 mL	11.1015 mL
20 mM	0.1110 mL	0.5551 mL	1.1101 mL	5.5507 mL
50 mM	0.0444 mL	0.2220 mL	0.4441 mL	2.2203 mL
100 mM	0.0222 mL	0.1110 mL	0.2220 mL	1.1101 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc