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Etelcalcetide hydrochloride (Synonyms: KAI-4169 hydrochloride, AMG 416 hydrochloride)

Name: Etelcalcetide hydrochloride
Brand: TargetMol
SKU: TP1236
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. TP1236 Copy Product Info

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Etelcalcetide hydrochloride (AMG 416 hydrochloride) is a synthetic peptide that serves as an allosteric modulator of the calcium-sensing receptor (CaSR), effectively reducing parathyroid hormone (PTH) levels in patients with secondary hyperparathyroidism undergoing hemodialysis.

Etelcalcetide hydrochloride

Copy Product Info

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Catalog No. TP1236

Synonyms KAI-4169 hydrochloride, AMG 416 hydrochloride

Cas No. 1334237-71-6

Pack Size	Price	USA Stock	Global Stock
1 mg	$30	In Stock	In Stock
5 mg	$68	In Stock	In Stock
10 mg	$105	In Stock	In Stock
25 mg	$198	In Stock	In Stock
50 mg	$347	In Stock	In Stock
100 mg	$572	In Stock	-

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:>99.99%

Appearance:solid

Color:White

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COA

Product Introduction

Bioactivity

Description	Etelcalcetide hydrochloride (AMG 416 hydrochloride) is a synthetic peptide that serves as an allosteric modulator of the calcium-sensing receptor (CaSR), effectively reducing parathyroid hormone (PTH) levels in patients with secondary hyperparathyroidism undergoing hemodialysis.
Synonyms	KAI-4169 hydrochloride, AMG 416 hydrochloride

Chemical Properties

Molecular Weight	1353.33
Formula	C₃₈H₇₃N₂₁O₁₀S₂.17/2HCl
Cas No.	1334237-71-6
Smiles	Cl.C[C@@H](NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](C)NC(=O)[C@@H](CSSC[C@H](N)C(O)=O)NC(C)=O)C(=O)N[C@H](CCCNC(N)=N)C(O)=O
Relative Density.	no data available
Sequence	{Cys1'}-Ac-{d-Cys1}-{d-Ala}-{d-Arg}-{d-Arg}-{d-Arg}-{d-Ala}-{d-Arg}-NH2 (Disulfide bridge: Cys1'-Cys1)
Sequence Short	C1' . Ac-{d-Cys1}-{d-Ala}-{d-Arg}-{d-Arg}-{d-Arg}-{d-Ala}-{d-Arg} (Disulfide bridge: Cys1'-Cys1)

Storage & Solubility Information

Storage

Keep away from moisture | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 250 mg/mL (184.73 mM), Sonication is recommended.

DMSO: Insoluble

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	0.7389 mL	3.6946 mL	7.3892 mL	36.9459 mL
5 mM	0.1478 mL	0.7389 mL	1.4778 mL	7.3892 mL
10 mM	0.0739 mL	0.3695 mL	0.7389 mL	3.6946 mL
20 mM	0.0369 mL	0.1847 mL	0.3695 mL	1.8473 mL
50 mM	0.0148 mL	0.0739 mL	0.1478 mL	0.7389 mL
100 mM	0.0074 mL	0.0369 mL	0.0739 mL	0.3695 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc