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NDI-091143

Name: NDI-091143
Brand: TargetMol
SKU: T7424
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7424Cas No. 2375840-87-0

NDI-091143 is a potent, high-affinity human ATP-citrate lyase (ACLY) inhibitor with an IC50 of 2.1 nM (ADP-Glo assay), indirectly disrupting citrate binding via an unexpected mechanism of inhibition.

NDI-091143

🥰Excellent

Purity: 98.61%

Catalog No. T7424Cas No. 2375840-87-0

NDI-091143 is a potent, high-affinity human ATP-citrate lyase (ACLY) inhibitor with an IC50 of 2.1 nM (ADP-Glo assay), indirectly disrupting citrate binding via an unexpected mechanism of inhibition.

Pack Size	Price	Availability
1 mg	$30	In Stock
5 mg	$61	In Stock
10 mg	$101	In Stock
25 mg	$198	In Stock
50 mg	$347	In Stock
100 mg	$393	In Stock
200 mg	$586	In Stock
1 mL x 10 mM (in DMSO)	$72	In Stock

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Batch Information

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Purity:98.61%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	NDI-091143 is a potent, high-affinity human ATP-citrate lyase (ACLY) inhibitor with an IC50 of 2.1 nM (ADP-Glo assay), indirectly disrupting citrate binding via an unexpected mechanism of inhibition.
Targets&IC50	ATP citrate lyase (human):2.1 nM

Chemical Properties

Molecular Weight	453.84
Formula	C₂₀H₁₄ClF₂NO₅S
Cas No.	2375840-87-0
Smiles	COC(=O)c1cc(Cl)c(O)c(c1)S(=O)(=O)Nc1cc(c(F)cc1F)-c1ccccc1
Relative Density.	no data available
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 91 mg/mL (200.51 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2034 mL	11.0171 mL	22.0342 mL	110.1710 mL
5 mM	0.4407 mL	2.2034 mL	4.4068 mL	22.0342 mL
10 mM	0.2203 mL	1.1017 mL	2.2034 mL	11.0171 mL
20 mM	0.1102 mL	0.5509 mL	1.1017 mL	5.5085 mL
50 mM	0.0441 mL	0.2203 mL	0.4407 mL	2.2034 mL
100 mM	0.0220 mL	0.1102 mL	0.2203 mL	1.1017 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc