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CAIX Inhibitor S4

Name: CAIX Inhibitor S4
Brand: TargetMol
SKU: T36758
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T36758Cas No. 1330061-67-0

Alias S4

CAIX Inhibitor S4 (S4) is an effective inhibitor of carbonic anhydrase IX/XII with a Ki of 7 nM and 2 nM, respectively. The Kis for CA II and CA I are 546 and 5600 nM.

CAIX Inhibitor S4

🥰Excellent

Purity: 99.07%

Catalog No. T36758Alias S4Cas No. 1330061-67-0

CAIX Inhibitor S4 (S4) is an effective inhibitor of carbonic anhydrase IX/XII with a Ki of 7 nM and 2 nM, respectively. The Kis for CA II and CA I are 546 and 5600 nM.

Pack Size	Price	Availability
2 mg	$34	In Stock
5 mg	$55	In Stock
10 mg	$97	In Stock
25 mg	$198	In Stock
50 mg	$372	In Stock
100 mg	$556	In Stock
500 mg	$1,220	In Stock
1 mL x 10 mM (in DMSO)	$61	In Stock

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Purity:99.07%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	CAIX Inhibitor S4 (S4) is an effective inhibitor of carbonic anhydrase IX/XII with a Ki of 7 nM and 2 nM, respectively. The Kis for CA II and CA I are 546 and 5600 nM.
Targets&IC50	CA XII:2 nM (Ki), CA II:546 nM (Ki), CA I:5600 nM (Ki), CA IX:7 nM (Ki)
In vitro	CAIX Inhibitor S4 (33 μM; 15-60 min) delays the cell spreading of MDA-MB-231 cells in anoxia but essentially not in normoxia. CAIX Inhibitor S4 (1, 10, 100 μM; 24 h) inhibits the proliferation of MDA-MB-231, HCT116 and HT29 cells in a dose-dependent manner with IC50s of 481 μM, >1000 μM, and 20 μM, respectively. CAIX Inhibitor S4 (3.3-33 μM; 24 h) inhibits the eGFP-MDA-MB-231 cell migration in anoxia in a concentration-dependent manner[1].
In vivo	CAIX Inhibitor S4 (10 mg/kg; i.p.) reduces lung metastasis in the orthotopic MDA-MB-231 mouse model without impacting primary tumor growth[1].
Synonyms	S4

Chemical Properties

Molecular Weight	335.38
Formula	C₁₅H₁₇N₃O₄S
Cas No.	1330061-67-0
Smiles	Cc1cc(C)cc(NC(=O)Nc2ccc(OS(N)(=O)=O)cc2)c1
Relative Density.	1.429 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 245 mg/mL (730.51 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9817 mL	14.9085 mL	29.8169 mL	149.0846 mL
5 mM	0.5963 mL	2.9817 mL	5.9634 mL	29.8169 mL
10 mM	0.2982 mL	1.4908 mL	2.9817 mL	14.9085 mL
20 mM	0.1491 mL	0.7454 mL	1.4908 mL	7.4542 mL
50 mM	0.0596 mL	0.2982 mL	0.5963 mL	2.9817 mL
100 mM	0.0298 mL	0.1491 mL	0.2982 mL	1.4908 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc