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Anti-NANOS2 Polyclonal Antibody
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Catalog No. TMAB-09224
Anti-NANOS2 Polyclonal Antibody is a Rabbit antibody targeting NANOS2. Anti-NANOS2 Polyclonal Antibody can be used in WB.
Anti-NANOS2 Polyclonal Antibody
Anti-NANOS2 Polyclonal Antibody
😃Good
Catalog No. TMAB-09224
Anti-NANOS2 Polyclonal Antibody is a Rabbit antibody targeting NANOS2. Anti-NANOS2 Polyclonal Antibody can be used in WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $223 | 7-10 days | 7-10 days | |
| 100 μL | $373 | 7-10 days | 7-10 days | |
| 200 μL | $528 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-NANOS2 Polyclonal Antibody is a Rabbit antibody targeting NANOS2. Anti-NANOS2 Polyclonal Antibody can be used in WB. |
| Ig Type | IgG |
| Reactivity | Mouse,Rat (predicted:Human) |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cytoplasm. Cytoplasm, P-body (Bysimilarity). Cytoplasm, perinuclear region. Note=Localizes atP-bodies during gonocyte development (By similarity). More abundantin perinuclear region of the cytoplasm of the germ cells of theadult testis. |
| Tissue Specificity | Testis and ovary. Expression found in severalspermatogenic stages: in cells on the periphery of the tubuleswhich could correspond to spermatogonia, in spermatocytes and inround spermatids (at protein level). |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | Required to support proliferation and self-renewal of proximal germ cells in males only. Probably regulates translation of specific mRNAs by associating with the 3'-UTR of mRNA targets. Essential for spermatogonia formation. |
| Immunogen | KLH conjugated synthetic peptide: human NANOS2 |
| Antigen Species | Human |
| Gene Name | NANOS2 |
| Gene ID | |
| Protein Name | Nanos homolog 2 |
| Uniprot ID | |
| Function | Plays a key role in the sexual differentiation of germcells by promoting the male fate but suppressing the female fate.Represses the female fate pathways by suppressing meiosis, which inturn results in the promotion of the male fate. Maintains thesuppression of meiosis by preventing STRA8 expression, which isrequired for premeiotic DNA replication, after CYP26B1 isdecreased. Regulates the localization of the CCR4-NOT deadenylationcomplex to P-bodies and plays a role in recruiting the complex totrigger the degradation of mRNAs involved in meiosis. Required forthe maintenance of the spermatogonial stem cell population. Notessential for the assembly of P-bodies but is required for themaintenance of their normal state (By similarity). |
| Molecular Weight | Theoretical: 15 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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