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Anti-14-3-3 sigma Antibody-PE (4U743)
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Catalog No. TMAY-01246P
Anti-14-3-3 sigma Antibody-PE (4U743) is a PE-conjugated Mouse antibody targeting 14-3-3 sigma. Anti-14-3-3 sigma Antibody-PE (4U743) can be used in FCM.
Anti-14-3-3 sigma Antibody-PE (4U743)
Anti-14-3-3 sigma Antibody-PE (4U743)
🥰Excellent
Catalog No. TMAY-01246P
Anti-14-3-3 sigma Antibody-PE (4U743) is a PE-conjugated Mouse antibody targeting 14-3-3 sigma. Anti-14-3-3 sigma Antibody-PE (4U743) can be used in FCM.
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Chemical Properties
| Description | Anti-14-3-3 sigma Antibody-PE (4U743) is a PE-conjugated Mouse antibody targeting 14-3-3 sigma. Anti-14-3-3 sigma Antibody-PE (4U743) can be used in FCM. |
| Ig Type | Monoclonal Mouse IgG1 |
| Clone | 4U743 |
| Reactivity | Human |
| Verified Activity | Flow cytometric analysis of Human SFN expression on HeLa cells. Cells were stained with PE-conjugated anti-Human SFN. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| Application | FCM |
| Recommended Dose | 10 μl/Test, 0.1 mg/ml |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human 14-3-3 sigma / Stratifin / YWHAS (rh 14-3-3 sigma / Stratifin / YWHAS; TMPY-01275; NP_006133.1; Met1-Ser248) and conjugated with PE under optimum conditions, the unreacted PE was removed. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | PBS solution containing 0.5% BSA and 0.09% sodium azide |
| Research Background | 14-3-3 protein sigma (YWHAS), also known as stratifin (SFN) and epithelial cell marker protein 1, is a member of the 14-3-3 proteins which are a family of conserved regulatory molecules expressed in all eukaryotic cells. The name 14-3-3 refers to the particular elution and migration pattern of these proteins on DEAE-cellulose chromatography and starch-gel electrophoresis. The 14-3-3 proteins eluted in the 14th fraction of bovine brain homogenate and were found on positions 3.3 of subsequent electrophoresis. There are seven genes that encode 14-3-3s in most mammals. 14-3-3 proteins have been identified as adapter proteins implicated in the regulation of a large spectrum of both general and specialized signaling pathways. More than 1 signaling proteins have been reported as 14-3-3 ligands including kinases, phosphatases, and transmembrane receptors, and the binding generally results in the modulation of the activity of the binding partner. YWHAE exists as a homodimer and present mainly in tissues enriched in stratified squamous keratinising epithelium. YWHAS has been repoted to interact with KRT17 and GAB2, and may regulate protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway upon binding to KRT17. Additionally, YWHAS (SFN) may also act as a p53-regulated inhibitor of G2/M progression. |
| Conjucates | PE |
| Others Formats | Unconjugated |
| Antibody Types Available | 2 |
| Immunogen | Recombinant Human 14-3-3 sigma / Stratifin / YWHAS Protein (TMPY-01275) |
| Antigen Species | Human |
| Biology Area | phospho-Serine/phospho-Threonine Binding Proteins, Adaptor Proteins, Apoptosis Adaptor Proteins |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal. |
| Transport | Shipping with blue ice. |
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