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Lauramine oxide
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Catalog No. T20936Cas No. 1643-20-5
Alias Refan, LDAO, Lauryldimethylamine oxide, Dimethylaurylamine oxide
Lauramine oxide (Refan) is effective against common bacteria such as E. coli and S. aureus, however it is non-denaturing and may be used to solubilize proteins.
Lauramine oxide
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Purity: 99.71%
Catalog No. T20936Alias Refan, LDAO, Lauryldimethylamine oxide, Dimethylaurylamine oxideCas No. 1643-20-5
Lauramine oxide (Refan) is effective against common bacteria such as E. coli and S. aureus, however it is non-denaturing and may be used to solubilize proteins.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 g | $29 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.71%
Appearance:Solid
Color:White
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Product Introduction
Lauramine oxide AI Summary
Lauramine oxide is a multifaceted bioactive molecule with significant inhibitory effects against various targets. It notably inhibits Oleoyl-CoA Synthetase (OSC) with an IC50 value of 2150.0 nM and demonstrates an 84.0% inhibitory effect at a concentration of 20 µM, underscoring its potency in this pathway. Additionally, it shows inhibitory activity on anti-DNP-IgE-induced degranulation in rat RBL2H3 cells, with a 40.0% inhibition rate observed at 25 µM after 30 minutes. The compound also interacts with several signaling pathways: it acts as an agonist of the retinoid X receptor alpha and the antioxidant response element (ARE) signaling pathway through Nrf2-dependent transcriptional activity, and an antagonist of androgen and glucocorticoid receptor signaling. Furthermore, it serves as an activator of both rat and human pregnane X receptor (PXR) signaling pathways. Moreover, in assays involving human OSC expressed in Saccharomyces cerevisiae, Lauramine oxide exhibited complete inhibition (100.0%) at 20 µM in one assay, 85.0% inhibition in another, and an IC50 value of 6310.0 nM. These diverse bioactivities highlight its potential as a multi-target therapeutic agent..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Lauramine oxide (Refan) is effective against common bacteria such as E. coli and S. aureus, however it is non-denaturing and may be used to solubilize proteins. |
| Synonyms | Refan, LDAO, Lauryldimethylamine oxide, Dimethylaurylamine oxide |
| Molecular Weight | 229.4 |
| Formula | C14H31NO |
| Cas No. | 1643-20-5 |
| Smiles | C(CCCCCCCCC)CCN(C)(C)=O |
| Relative Density. | 0.996 g/cm3 at 20℃ |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||||||||||||
| Solubility Information | DMSO: 2.3 mg/mL (10.03 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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