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QPRTase Protein, Human, Recombinant (His)
(Synonyms: Quinolinate Phosphoribosyltransferase [Decarboxylating], QPRTase, QPRT, QAPRTase, Nicotinate-Nucleotide Pyrophosphorylase [Carboxylating]) Copy Product InfoSynonyms: Quinolinate Phosphoribosyltransferase [Decarboxylating], QPRTase, QPRT, QAPRTase, Nicotinate-Nucleotide Pyrophosphorylase [Carboxylating]
Catalog No. TMPJ-00473 Copy Product Info
Nicotinate-Nucleotide Pyrophosphorylase (QPRT) belongs to the nadC/modD family. QPRT plays an improtant role in catabolism of quinolinate which acts as a potent endogenous exitotoxin to neurons. In addition, QPRT serves as an an intermediate in the Tryptophan-Nicotinamide Adenine Dinucleotide pathway. QPRT participates in some pathways including Cofactor biosynthesis, NAD(+) biosynthesis and the Nicotinate D-Ribonucleotide from Quinolinate. In addition, QPRT is involved in the catabolism of Quinolinic Acid (QA). The activity toward QA is slightly repressed by phosphoribosylpyrophosphate (PRPP) in both a competitive and a non-competitive manner.
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 μg | $112 | 6-8 weeks | 6-8 weeks | |
| 10 μg | $183 | 6-8 weeks | 6-8 weeks | |
| 20 μg | $292 | 6-8 weeks | 6-8 weeks | |
| 50 μg | $545 | 6-8 weeks | 6-8 weeks | |
| 100 μg | $792 | 6-8 weeks | 6-8 weeks | |
| 200 μg | $1,150 | 6-8 weeks | 6-8 weeks | |
| 500 μg | $1,900 | 6-8 weeks | 6-8 weeks | |
| 1 mg | $2,730 | 6-8 weeks | 6-8 weeks |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Nicotinate-Nucleotide Pyrophosphorylase (QPRT) belongs to the nadC/modD family. QPRT plays an improtant role in catabolism of quinolinate which acts as a potent endogenous exitotoxin to neurons. In addition, QPRT serves as an an intermediate in the Tryptophan-Nicotinamide Adenine Dinucleotide pathway. QPRT participates in some pathways including Cofactor biosynthesis, NAD(+) biosynthesis and the Nicotinate D-Ribonucleotide from Quinolinate. In addition, QPRT is involved in the catabolism of Quinolinic Acid (QA). The activity toward QA is slightly repressed by phosphoribosylpyrophosphate (PRPP) in both a competitive and a non-competitive manner. |
| Species | Human |
| Expression System | E. coli |
| Tag | N-6xHis |
| Accession Number | AAH05060.1 |
| Amino Acid | Met1-His297 |
| Construction | Met1-His297 |
| Protein Purity | Greater than 95% as determined by reducing SDS-PAGE. (QC verified) |
| Endotoxin | < 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20 mM Tris-HCl, 150 mM NaCl, pH 8.0. |
| Stability & Storage | Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
| Shipping | Proteins are shipped with blue ice. |
| Synonyms | Quinolinate Phosphoribosyltransferase [Decarboxylating], QPRTase, QPRT, QAPRTase, Nicotinate-Nucleotide Pyrophosphorylase [Carboxylating] |
| Research Background |
| Molecular Weight | 34 KDa (reducing condition) |
| Storage | Store at low temperature Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: QPRTase Protein, Human, Recombinant (His) chemical structure | QPRTase Protein, Human, Recombinant (His) molecular weight
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