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PDGFR Tyrosine Kinase Inhibitor III

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Catalog No. T60108Cas No. 205254-94-0
Alias PDGF Receptor Tyrosine Kinase Inhibitor III

PDGFR Tyrosine Kinase Inhibitor III (PDGF Receptor Tyrosine Kinase Inhibitor III) is a multikinase inhibitor that inhibits PDGFR, EGFR, FGFR, PKA, and PKC and can be used for research on amyotrophic lateral sclerosis [1].

PDGFR Tyrosine Kinase Inhibitor III

PDGFR Tyrosine Kinase Inhibitor III

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Purity: 99.50%
Catalog No. T60108Alias PDGF Receptor Tyrosine Kinase Inhibitor IIICas No. 205254-94-0
PDGFR Tyrosine Kinase Inhibitor III (PDGF Receptor Tyrosine Kinase Inhibitor III) is a multikinase inhibitor that inhibits PDGFR, EGFR, FGFR, PKA, and PKC and can be used for research on amyotrophic lateral sclerosis [1].
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
5 mg$40In StockIn Stock
10 mg$64In StockIn Stock
25 mg$129In StockIn Stock
50 mg$213In StockIn Stock
100 mg$342In StockIn Stock
1 mL x 10 mM (in DMSO)$42In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:99.50%
Appearance:Solid
Color:White
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COA HNMR LCMS

Product Introduction

PDGFR Tyrosine Kinase Inhibitor III AI Summary
PDGFR Tyrosine Kinase Inhibitor III inhibits the phosphorylation of platelet-derived growth factor receptor beta (PDGFRβ) in intact cells with an IC50 value of 80.0 nM. It also inhibits PDGFRβ phosphorylation in CHO cells with an IC50 greater than 80.0 nM. Additionally, it targets other receptors and kinases, including platelet-derived growth factor receptor alpha (IC50 50.0 nM), mast/stem cell growth factor receptor (c-Kit kinase, IC50 50.0 nM), Flt3 kinase (IC50 230.0 nM), and PDGF-BB-induced proliferation of porcine aorta smooth muscle cells (IC50 250.0 nM). PDGFR Tyrosine Kinase Inhibitor III exhibits low activity against the epidermal growth factor receptor, fibroblast growth factor receptor kinase, Src protein tyrosine kinase, protein kinase A (PKA), and protein kinase C, with IC50 values greater than 30,000.0 nM. It also demonstrates varying potencies as an inhibitor in assays involving TGF-β, human tyrosyl-DNA phosphodiesterase 1 (TDP1) in the presence and absence of CPT, and stage-specific inhibitors of Vaccinia Orthopoxvirus, with IC50 values ranging from 10,000.0 nM to 12,589.3 nM..
Note: Summary generated by AI. Data source: ChEMBL
Bioactivity
Description
PDGFR Tyrosine Kinase Inhibitor III (PDGF Receptor Tyrosine Kinase Inhibitor III) is a multikinase inhibitor that inhibits PDGFR, EGFR, FGFR, PKA, and PKC and can be used for research on amyotrophic lateral sclerosis [1].
SynonymsPDGF Receptor Tyrosine Kinase Inhibitor III
Chemical Properties
Molecular Weight485.53
FormulaC27H27N5O4
Cas No.205254-94-0
SmilesO(C)C1=CC=2C(=NC=NC2C=C1OC)N3CCN(C(NC4=CC=C(OC5=CC=CC=C5)C=C4)=O)CC3
Relative Density.1.310 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 50 mg/mL (102.98 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2.06 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.0596 mL10.2980 mL20.5960 mL102.9802 mL
5 mM0.4119 mL2.0596 mL4.1192 mL20.5960 mL
10 mM0.2060 mL1.0298 mL2.0596 mL10.2980 mL
20 mM0.1030 mL0.5149 mL1.0298 mL5.1490 mL
50 mM0.0412 mL0.2060 mL0.4119 mL2.0596 mL
100 mM0.0206 mL0.1030 mL0.2060 mL1.0298 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

PDGFR Tyrosine Kinase Inhibitor IIIPDGFR
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