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Anti-B7-H3 Antibody (8G959)
😃Good
Catalog No. TMAH-00187
Alias UNQ309, PSEC0249, PRO352, CD276, B7-H3, B7 homolog 3, 4Ig-B7-H3
Anti-B7-H3 Antibody (8G959) is an antibody targeting B7-H3. Anti-B7-H3 Antibody (8G959) can be used in ELISA.
Anti-B7-H3 Antibody (8G959)
Anti-B7-H3 Antibody (8G959)
😃Good
Catalog No. TMAH-00187Alias UNQ309, PSEC0249, PRO352, CD276, B7-H3, B7 homolog 3, 4Ig-B7-H3
Anti-B7-H3 Antibody (8G959) is an antibody targeting B7-H3. Anti-B7-H3 Antibody (8G959) can be used in ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $208 | 7-10 days | |
| 100 μL | $349 | 7-10 days |
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Product Introduction
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Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-B7-H3 Antibody (8G959) is an antibody targeting B7-H3. Anti-B7-H3 Antibody (8G959) can be used in ELISA. |
| Synonyms | UNQ309, PSEC0249, PRO352, CD276, B7-H3, B7 homolog 3, 4Ig-B7-H3 |
| Ig Type | hIgG1 |
| Clone | 8G959 |
| Reactivity | Human, Cynomolgus |
| Verified Activity | 1. The Binding Activity of Human CD276 with Anti-CD276 recombinant antibody Activity: Measured by its binding ability in a functional ELISA. Immobilized human CD276 at 2 μg/mL can bind Anti-CD276 recombinant antibody. The EC50 is 4.299-5.373 ng/mL. 2. The Binding Activity of Human CD276 with Anti-CD276 recombinant antibody Activity: Measured by its binding ability in a functional ELISA. Immobilized human CD276 at 2 μg/mL can bind Anti-CD276 recombinant antibody. The EC50 is 47.12-54.16 ng/mL. 3. Overlay Peak curve showing MCF7 cells stained with TMAH-00187MA1HU (red line) at 1:100. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*10^6 cells) for 45min at 4°C. The secondary antibody used was FITC-conjugated Goat Anti-human IgG(H+L) at 1:200 dilution for 35min at 4°C.Control antibody (green line) was human IgG (1ug/1*10^6 cells) used under the same conditions. Acquisition of >10,000 events was performed. |
| Application | |
| Recommended Dose | ELISA:1:5000-1:50000. |
| Antibody Type | Monoclonal |
| Subcellular Localization | Membrane; Single-pass type I membrane protein. |
| Tissue Specificity | Ubiquitous but not detectable in peripheral blood lymphocytes or granulocytes. Weakly expressed in resting monocytes. Expressed in dendritic cells derived from monocytes. Expressed in epithelial cells of sinonasal tissue. Expressed in extravillous trophob |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. |
| Research Background | Earlier studies found that B7H3 (also known as B7H3) promotes the activation of T cells. Chapoval et al. confirmed that in the presence of anti-CD3 antibodies, B7H3 can promote the proliferation of CD4 and CD8+ T cells and selectively promote the secretion of IFN-γ. And B7H3 transfection into tumor cells can enhance the killing ability of CTL. Further research found that only TLT-2 transgenic cells could bind to mouse B7H3 with high affinity, and TLT-2 was determined to be the receptor molecule of B7H3. Moreover, Hashiguchi et al. confirmed that the B7H3-TLT-2 pathway enhanced T cell activation. However, Leitner et al. did not find the specific binding of B7H3 to TLT-2 by flow cytometry, therefore, the exact receptor molecule of B7H3 is still unclear. On the other hand, studies have found that B7H3 can also suppress T-cell immune responses. Some studies have shown that B7H3 can inhibit human and mouse T cells by activating or inhibiting NFTA (nuclear factor for activated T cells), NF-KB (nuclear factor kB) and AP-1 (activator protein-1) pathways. activation. In addition, results have demonstrated that B7H3 may inhibit T cell immune responses by inhibiting the activity of Thl. The study of Leiner et al. also found that B7H3 can down-regulate the secretion of IL-2 in T cells to inhibit the activity of T cells. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human CD276 Protein |
| Antigen Species | Human |
| Gene Name | CD276 |
| Gene ID | |
| Uniprot ID | |
| Biology Area | Cancer, Immunology, Stem cells |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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