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MLS1547

Name: MLS1547
Brand: TargetMol
SKU: T28073
Price: 45 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T28073Cas No. 315698-36-3

Alias MLS-1547, MLS000051547, MLS 1547

MLS1547 (MLS000051547) is a highly efficacious agonist of G protein-biased dopamine D2 receptor with a Ki of 1.2 μM. MLS1547 stimulates D2R G protein-mediated signaling with EC50 of 0.37 μM in a calcium mobilization assay.

MLS1547

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Purity: 99.64%

Catalog No. T28073Alias MLS-1547, MLS000051547, MLS 1547Cas No. 315698-36-3

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
25 mg	$45	In Stock	In Stock
50 mg	Preferential	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.64%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	MLS1547 (MLS000051547) is a highly efficacious agonist of G protein-biased dopamine D2 receptor with a Ki of 1.2 μM. MLS1547 stimulates D2R G protein-mediated signaling with EC50 of 0.37 μM in a calcium mobilization assay.
In vitro	MLS1547 fully antagonizes dopamine-mediated β-arrestin recruitment to the D2 dopamine receptor, with an IC50 of 9.9 μM in the DiscoveRx assay and 3.8 μM in the BRET assay, and completely displaces [3H]methylspiperone binding to the D2 dopamine receptor, with a Ki of 1.2 μM[2].
Synonyms	MLS-1547, MLS000051547, MLS 1547

Chemical Properties

Molecular Weight	354.83
Formula	C₁₉H₁₉ClN₄O
Cas No.	315698-36-3
Smiles	Oc1c(CN2CCN(CC2)c2ccccn2)cc(Cl)c2cccnc12
Relative Density.	1.354 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (126.82 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2.82 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8183 mL	14.0913 mL	28.1825 mL	140.9125 mL
5 mM	0.5637 mL	2.8183 mL	5.6365 mL	28.1825 mL
10 mM	0.2818 mL	1.4091 mL	2.8183 mL	14.0913 mL
20 mM	0.1409 mL	0.7046 mL	1.4091 mL	7.0456 mL
50 mM	0.0564 mL	0.2818 mL	0.5637 mL	2.8183 mL
100 mM	0.0282 mL	0.1409 mL	0.2818 mL	1.4091 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc