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Sangivamycin

Name: Sangivamycin
Brand: TargetMol
SKU: T9605
Price: 128 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9605Cas No. 18417-89-5

Alias NSC 65346, BA-90912

Sangivamycin (NSC-65346) is an effective inhibitor of protein kinase C (PKC, Ki = 10 μM). Sangivamycin exhibits antiproliferative activity against a variety of human cancers.

Sangivamycin

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Purity: 99.85%

Catalog No. T9605Alias NSC 65346, BA-90912Cas No. 18417-89-5

Sangivamycin (NSC-65346) is an effective inhibitor of protein kinase C (PKC, Ki = 10 μM). Sangivamycin exhibits antiproliferative activity against a variety of human cancers.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$128	In Stock	In Stock
5 mg	$289	In Stock	In Stock
10 mg	$438	In Stock	In Stock
25 mg	$712	In Stock	In Stock
50 mg	$993	In Stock	In Stock
100 mg	$1,330	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$379	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.85%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Sangivamycin (NSC-65346) is an effective inhibitor of protein kinase C (PKC, Ki = 10 μM). Sangivamycin exhibits antiproliferative activity against a variety of human cancers.
Targets&IC50	PKC:10 μM(Ki)
In vitro	Sangivamycin (0.3 μM; 0-72 hours) exhibits a predominantly cytocidal effect in multidrug-resistant MCF7/adriamycin-resistant (ADR) human breast carcinoma cells, and a cytostatic effect in drug-sensitive MCF7/wild type (WT) cells. In MCF7/ADR cells, Sangivamycin triggers caspase activation, leading to significant cleavage of lamin A into a 28-kDa fragment within 48 hours. These findings highlight Sangivamycin's differential antitumor activities, inducing apoptosis-driven cell death in MCF7/ADR cells and growth arrest in MCF7/WT cells.
Synonyms	NSC 65346, BA-90912

Chemical Properties

Molecular Weight	309.28
Formula	C₁₂H₁₅N₅O₅
Cas No.	18417-89-5
Smiles	NC(=O)c1cn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c2ncnc(N)c12
Relative Density.	1.3120 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 120 mg/mL (388 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (10.67 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2333 mL	16.1666 mL	32.3332 mL	161.6658 mL
5 mM	0.6467 mL	3.2333 mL	6.4666 mL	32.3332 mL
10 mM	0.3233 mL	1.6167 mL	3.2333 mL	16.1666 mL
20 mM	0.1617 mL	0.8083 mL	1.6167 mL	8.0833 mL
50 mM	0.0647 mL	0.3233 mL	0.6467 mL	3.2333 mL
100 mM	0.0323 mL	0.1617 mL	0.3233 mL	1.6167 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc