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Sangivamycin

Name: Sangivamycin
Brand: TargetMol
SKU: T9605
Price: 128 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9605Cas No. 18417-89-5

Alias NSC 65346, BA-90912

Sangivamycin (NSC-65346) is an effective inhibitor of protein kinase C (PKC, Ki = 10 μM). Sangivamycin exhibits antiproliferative activity against a variety of human cancers.

Sangivamycin

🥰Excellent

Purity: 99.85%

Catalog No. T9605Alias NSC 65346, BA-90912Cas No. 18417-89-5

Sangivamycin (NSC-65346) is an effective inhibitor of protein kinase C (PKC, Ki = 10 μM). Sangivamycin exhibits antiproliferative activity against a variety of human cancers.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$128	In Stock	In Stock
5 mg	$289	In Stock	In Stock
10 mg	$438	In Stock	In Stock
25 mg	$712	In Stock	In Stock
50 mg	$993	In Stock	In Stock
100 mg	$1,330	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$379	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.85%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Sangivamycin (NSC-65346) is an effective inhibitor of protein kinase C (PKC, Ki = 10 μM). Sangivamycin exhibits antiproliferative activity against a variety of human cancers.
Targets&IC50	PKC:10 μM(Ki)
In vitro	Sangivamycin (0.3 μM; 0-72 hours) exhibits a predominantly cytocidal effect in multidrug-resistant MCF7/adriamycin-resistant (ADR) human breast carcinoma cells, and a cytostatic effect in drug-sensitive MCF7/wild type (WT) cells. In MCF7/ADR cells, Sangivamycin triggers caspase activation, leading to significant cleavage of lamin A into a 28-kDa fragment within 48 hours. These findings highlight Sangivamycin's differential antitumor activities, inducing apoptosis-driven cell death in MCF7/ADR cells and growth arrest in MCF7/WT cells.
Synonyms	NSC 65346, BA-90912

Chemical Properties

Molecular Weight	309.28
Formula	C₁₂H₁₅N₅O₅
Cas No.	18417-89-5
Smiles	NC(=O)c1cn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c2ncnc(N)c12
Relative Density.	1.3120 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 95 mg/mL (307.17 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (10.67 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2333 mL	16.1666 mL	32.3332 mL	161.6658 mL
5 mM	0.6467 mL	3.2333 mL	6.4666 mL	32.3332 mL
10 mM	0.3233 mL	1.6167 mL	3.2333 mL	16.1666 mL
20 mM	0.1617 mL	0.8083 mL	1.6167 mL	8.0833 mL
50 mM	0.0647 mL	0.3233 mL	0.6467 mL	3.2333 mL
100 mM	0.0323 mL	0.1617 mL	0.3233 mL	1.6167 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc