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L-SelenoMethionine

Name: L-SelenoMethionine
Brand: TargetMol
SKU: T5372
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5372Cas No. 3211-76-5

Alias L-(+)-Selenomethionine

L-SelenoMethionine (L-(+)-Selenomethionine) is a naturally occurring amino acid. It promotes cell cycle progression and elevates the expression of the antioxidant enzymes thioredoxin reductase, glutathione reductase.

L-SelenoMethionine

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Purity: 99.67%

Catalog No. T5372Alias L-(+)-SelenomethionineCas No. 3211-76-5

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$30	In Stock	In Stock
100 mg	$42	In Stock	In Stock
500 mg	$125	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.67%

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	L-SelenoMethionine (L-(+)-Selenomethionine) is a naturally occurring amino acid. It promotes cell cycle progression and elevates the expression of the antioxidant enzymes thioredoxin reductase, glutathione reductase.
In vitro	At 5 μM, L-selenomethionine selectively induces apoptosis in LNCaP prostate cancer cells without affecting non-cancerous cells [1]. c-Myc, cyclin C, proliferating cell nuclear antigen, cyclin-dependent kinase (cdk)1, cdk2, cdk4, cyclin B and cyclin D2 mRNA levels were lower in selenium-deficient cells than in the cells supplemented with 0.25 micromol/L selenomethionine. The phosphorylation state of total cellular protein was higher (57%) in selenium-supplemented cells than in selenium-deficient cells [2].
Synonyms	L-(+)-Selenomethionine

Chemical Properties

Molecular Weight	196.11
Formula	C₅H₁₁NO₂Se
Cas No.	3211-76-5
Smiles	[C@@H](C(O)=O)(CC[Se]C)N
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: < 1 mg/mL (insoluble or slightly soluble), Sonication is recommended.

H2O: 27.5 mg/mL (140.23 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	5.0992 mL	25.4959 mL	50.9918 mL	254.9590 mL
5 mM	1.0198 mL	5.0992 mL	10.1984 mL	50.9918 mL
10 mM	0.5099 mL	2.5496 mL	5.0992 mL	25.4959 mL
20 mM	0.2550 mL	1.2748 mL	2.5496 mL	12.7479 mL
50 mM	0.1020 mL	0.5099 mL	1.0198 mL	5.0992 mL
100 mM	0.0510 mL	0.2550 mL	0.5099 mL	2.5496 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc