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BI-3812

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Catalog No. T14561Cas No. 2166387-64-8

BI-3812 is an inhibitor of BCL6. Which inhibiting the BTB domain of BCL6 (IC50: 3 nM). BI-3812 also has antitumor activity.

BI-3812

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Purity: 98.22%

Catalog No. T14561Cas No. 2166387-64-8

BI-3812 is an inhibitor of BCL6. Which inhibiting the BTB domain of BCL6 (IC50: 3 nM). BI-3812 also has antitumor activity.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$112	In Stock	In Stock
2 mg	$165	In Stock	In Stock
5 mg	$263	In Stock	In Stock
10 mg	$447	In Stock	In Stock
25 mg	$739	In Stock	In Stock
50 mg	$987	In Stock	In Stock
100 mg	$1,390	-	In Stock
1 mL x 10 mM (in DMSO)	$323	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:98.22%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	BI-3812 is an inhibitor of BCL6. Which inhibiting the BTB domain of BCL6 (IC50: 3 nM). BI-3812 also has antitumor activity.
Targets&IC50	Bcl-6 BTB:≤3 nM (IC50)
In vivo	BI-3812 is a BCL6 inhibitor with an IC50 of ≤3 nM, and demonstrates an IC50 of 40 nM for cellular BCL6[1].

Chemical Properties

Molecular Weight	558.03
Formula	C₂₆H₃₂ClN₇O₅
Cas No.	2166387-64-8
Smiles	CNC(=O)COc1cc2cc(Nc3nc(ncc3Cl)N3CCC(CC3)C(=O)N(C)C)cc(OC)c2n(C)c1=O
Relative Density.	1.40 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 19.83 mg/mL (35.54 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 1.5 mg/mL (2.69 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7920 mL	8.9601 mL	17.9202 mL	89.6009 mL
5 mM	0.3584 mL	1.7920 mL	3.5840 mL	17.9202 mL
10 mM	0.1792 mL	0.8960 mL	1.7920 mL	8.9601 mL
20 mM	0.0896 mL	0.4480 mL	0.8960 mL	4.4800 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc