Shopping Cart

Remove All
Your shopping cart is currently empty

Aurintricarboxylic acid

Name: Aurintricarboxylic acid
Brand: TargetMol
SKU: T8333
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T8333Cas No. 4431-00-9

Alias NSC-4056, NSC4056, NSC 4056, ATA

Aurintricarboxylic acid (NSC-4056) is a strong inhibitor of topoisomerases and other nucleases. It is a potent inhibitor of ribonuclease and topoisomerase II by preventing the binding of the nucleic acid to the enzyme.

Aurintricarboxylic acid

🥰Excellent

Purity: 97.1%

Catalog No. T8333Alias NSC-4056, NSC4056, NSC 4056, ATACas No. 4431-00-9

Pack Size	Price	Availability
50 mg	$30	In Stock
100 mg	$43	In Stock
200 mg	$61	In Stock
500 mg	$97	In Stock
1 mL x 10 mM (in DMSO)	$48	In Stock

Add to Cart

Add to Quotation

Bulk & Custom

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:97.1%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	Aurintricarboxylic acid (NSC-4056) is a strong inhibitor of topoisomerases and other nucleases. It is a potent inhibitor of ribonuclease and topoisomerase II by preventing the binding of the nucleic acid to the enzyme.
Targets&IC50	MicroRNA:0.47 μM, P2X1 (rat):8.6 nM, P2X3 (rat):72.9 nM
In vitro	Aurintricarboxylic acid (ATA) is a known Stp1 inhibitor with an IC50 of 1.03 μM[1].
Synonyms	NSC-4056, NSC4056, NSC 4056, ATA

Chemical Properties

Molecular Weight	422.34
Formula	C₂₂H₁₄O₉
Cas No.	4431-00-9
Smiles	OC(=O)C1=CC(C=CC1=O)=C(c1ccc(O)c(c1)C(O)=O)c1ccc(O)c(c1)C(O)=O
Relative Density.	1.65g/cm3
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (295.97 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (9.47 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3678 mL	11.8388 mL	23.6776 mL	118.3880 mL
5 mM	0.4736 mL	2.3678 mL	4.7355 mL	23.6776 mL
10 mM	0.2368 mL	1.1839 mL	2.3678 mL	11.8388 mL
20 mM	0.1184 mL	0.5919 mL	1.1839 mL	5.9194 mL
50 mM	0.0474 mL	0.2368 mL	0.4736 mL	2.3678 mL
100 mM	0.0237 mL	0.1184 mL	0.2368 mL	1.1839 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc