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Anti-LRP2 Antibody (2U476)
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Catalog No. TMAB-08400
Anti-LRP2 Antibody (2U476) is a Rabbit antibody targeting LRP2. Anti-LRP2 Antibody (2U476) can be used in IHC-P,WB,IF,IHC-Fr,ICC/IF.
Anti-LRP2 Antibody (2U476)
Anti-LRP2 Antibody (2U476)
Copy Product Info😃Good
Catalog No. TMAB-08400
Anti-LRP2 Antibody (2U476) is a Rabbit antibody targeting LRP2. Anti-LRP2 Antibody (2U476) can be used in IHC-P,WB,IF,IHC-Fr,ICC/IF.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 200 μg | $1,060 | 7-10 days | 7-10 days | |
| 25 μL | $148 | 7-10 days | 7-10 days | |
| 50 μL | $262 | 7-10 days | 7-10 days | |
| 100 μL | $473 | 7-10 days | 7-10 days | |
| 200 μL | $757 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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| Description | Anti-LRP2 Antibody (2U476) is a Rabbit antibody targeting LRP2. Anti-LRP2 Antibody (2U476) can be used in IHC-P,WB,IF,IHC-Fr,ICC/IF. |
| Ig Type | IgG |
| Clone | 2U476 |
| Reactivity | Mouse,Rat,Human |
| Verified Activity | 1. Sample: Lane 1: Recombinant mouse LRP2 protein, N-His Primary: Anti-LRP2 (TMAB-08400) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 519 kDa Observed band size: 26 kDa 2. (Negative control) paraformaldehyde-fixed, paraffin embedded Human Skeletal muscle; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with LRP2 Monoclonal Antibody, Unconjugated (TMAB-08400) at 1: 200 overnight at 4°C, followed by conjugation to the SP Kit (Rabbit) and DAB staining. 3. (Negative control) paraformaldehyde-fixed, paraffin embedded Mouse Skeletal muscle; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with LRP2 Monoclonal Antibody, Unconjugated (TMAB-08400) at 1: 200 overnight at 4°C, followed by conjugation to the SP Kit (Rabbit) and DAB staining. 4. (Negative control) paraformaldehyde-fixed, paraffin embedded Rat Skeletal muscle; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with LRP2 Monoclonal Antibody, Unconjugated (TMAB-08400) at 1: 200 overnight at 4°C, followed by conjugation to the SP Kit (Rabbit) and DAB staining. 5. Paraformaldehyde-fixed, paraffin embedded Human Kidney; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with LRP2 Monoclonal Antibody, Unconjugated (TMAB-08400) at 1: 200 overnight at 4°C, followed by conjugation to the SP Kit (Rabbit) and DAB staining. 6. Paraformaldehyde-fixed, paraffin embedded Mouse Kidney; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with LRP2 Monoclonal Antibody, Unconjugated (TMAB-08400) at 1: 200 overnight at 4°C, followed by conjugation to the SP Kit (Rabbit) and DAB staining. 7. Paraformaldehyde-fixed, paraffin embedded Rat Kidney; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with LRP2 Monoclonal Antibody, Unconjugated (TMAB-08400) at 1: 200 overnight at 4°C, followed by conjugation to the SP Kit (Rabbit) and DAB staining. 8. Paraformaldehyde-fixed, paraffin embedded Human Placenta; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with LRP2 Monoclonal Antibody, Unconjugated (TMAB-08400) at 1: 200 overnight at 4°C, followed by conjugation to the SP Kit (Rabbit) and DAB staining. 9. Paraformaldehyde-fixed, paraffin embedded Mouse kidney; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Blocking buffer (normal goat serum) at 37°C for 30 min; Incubation with LRP2 Monoclonal Antibody, Unconjugated (TMAB-08400) at 1: 200 overnight at 4°C, followed by a Cy3 conjugated Goat Anti-Rabbit IgG antibody for 90 minutes, and DAPI for nuclei staining. 10. Paraformaldehyde-fixed, paraffin embedded Rat kidney; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Blocking buffer (normal goat serum) at 37°C for 30 min; Incubation with LRP2 Monoclonal Antibody, Unconjugated (TMAB-08400) at 1: 200 overnight at 4°C, followed by a Cy3 conjugated Goat Anti-Rabbit IgG antibody for 90 minutes, and DAPI for nuclei staining. 11. Paraformaldehyde-fixed, paraffin embedded Human kidney; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Blocking buffer (normal goat serum) at 37°C for 30 min; Incubation with LRP2 Monoclonal Antibody, Unconjugated (TMAB-08400) at 1: 200 overnight at 4°C, followed by a Cy3 conjugated Goat Anti-Rabbit IgG antibody for 90 minutes, and DAPI for nuclei staining. |
| Application | |
| Recommended Dose | IHC-P: 1:100-500; WB: 1:500-2000; IF: 1:100-500; IHC-Fr: 1:100-500; ICC/IF: 1:50-200 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Membrane; Single-pass type I membrane protein. Membrane, coated pit. |
| Tissue Specificity | Absorptive epithelia, including renal proximal tubules. |
| Construction | Recombinant Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR).[provided by RefSeq, Aug 2009]. |
| Immunogen | Recombinant Protein: mouse LRP2 protein |
| Antigen Species | Mouse |
| Gene Name | LRP2 |
| Gene ID | |
| Protein Name | Low-density lipoprotein receptor-related protein 2 |
| Uniprot ID | |
| Function | Acts together with cubilin to mediate HDL endocytosis (By similarity). May participate in regulation of parathyroid-hormone and para-thyroid-hormone-related protein release. |
| Molecular Weight | Theoretical: 519 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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