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Cyanoacetohydrazide

Name: Cyanoacetohydrazide
Brand: TargetMol
SKU: T0704
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0704Cas No. 140-87-4

Alias Cyanoacetic hydrazide, 2-Cyanoacetohydrazide

Cyanoacetohydrazide (Cyanoacetic hydrazide) is an anti-TB drug. It has also been used to derive compounds that may have antitumor properties.

Cyanoacetohydrazide

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Purity: 99.78%

Catalog No. T0704Alias Cyanoacetic hydrazide, 2-CyanoacetohydrazideCas No. 140-87-4

Cyanoacetohydrazide (Cyanoacetic hydrazide) is an anti-TB drug. It has also been used to derive compounds that may have antitumor properties.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 g	$29	-	In Stock

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.78%

Appearance:Solid

Color:Yellow

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COA LCMS HNMR

Product Introduction

Cyanoacetohydrazide AI Summary

Cyanoacetohydrazide demonstrates multi-faceted bioactivities, including antiviral, enzymatic inhibitory, and anti-cytotoxic effects. It exhibits significant inhibition of Glutaminase (GLS) with a potency of 15848.9 nM. In assays targeting the Ebola virus, Cyanoacetohydrazide shows AC50 values ranging from 2511.9 nM to 3.981 µM. Its antiviral properties extend to SARS-CoV-2, where it inhibits induced cytotoxicity in both Caco-2 and VERO-6 cells at a 10 µM concentration, achieving inhibition rates of -1.94% and 0.21%, respectively. Moreover, the compound shows limited inhibition of the SARS-CoV-2 3CL-Pro protease, with a 12.61% inhibition observed at 20 µM. Additionally, Cyanoacetohydrazide inhibits human HDAC6 enzymatic activity with a substantial inhibition of -66.26% using a commercial peptide substrate, though a lesser inhibition of -1.29% is noted with a custom peptide substrate. The IC50 values for inhibiting SARS-CoV-2 induced cytotoxicity in VERO-6 cells are greater than 20000.0 nM and 19952.62 nM, underscoring potential antiviral effects at higher concentrations..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Cyanoacetohydrazide (Cyanoacetic hydrazide) is an anti-TB drug. It has also been used to derive compounds that may have antitumor properties.
Synonyms	Cyanoacetic hydrazide, 2-Cyanoacetohydrazide

Chemical Properties

Molecular Weight	99.09
Formula	C₃H₅N₃O
Cas No.	140-87-4
Smiles	NNC(=O)CC#N
Relative Density.	1.222 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (454.13 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (20.18 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	10.0918 mL	50.4592 mL	100.9184 mL	504.5918 mL
5 mM	2.0184 mL	10.0918 mL	20.1837 mL	100.9184 mL
10 mM	1.0092 mL	5.0459 mL	10.0918 mL	50.4592 mL
20 mM	0.5046 mL	2.5230 mL	5.0459 mL	25.2296 mL
50 mM	0.2018 mL	1.0092 mL	2.0184 mL	10.0918 mL
100 mM	0.1009 mL	0.5046 mL	1.0092 mL	5.0459 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc