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Nisoxetine hydrochloride

Name: Nisoxetine hydrochloride
Brand: TargetMol
SKU: T23070
Price: 64 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T23070Cas No. 57754-86-6

Nisoxetine hydrochloride is a noradrenaline transporter (NET) inhibitor

Nisoxetine hydrochloride

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Purity: 99.21%

Catalog No. T23070Cas No. 57754-86-6

Nisoxetine hydrochloride is a noradrenaline transporter (NET) inhibitor

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$64	In Stock	In Stock
10 mg	$97	In Stock	In Stock
25 mg	$178	In Stock	In Stock
50 mg	$288	In Stock	In Stock
100 mg	$457	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.21%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Nisoxetine hydrochloride AI Summary

Nisoxetine hydrochloride exhibits a wide range of bioactivities. It demonstrates antiplasmodial activity against various strains of Plasmodium falciparum, with IC50 values ranging from 794.33 nM to 12589.25 nM based on SYBR green assays over 72 hours. It inhibits Lipid Storage Modulators with a potency of 22387.2 nM and shows activity against the human hERG Channel at 6309.6 nM. Additionally, it inhibits Marburg Virus binding or entry into cells with variable potencies and inhibits Hepatitis C Virus (HCV) at 316.2 nM. Moreover, it acts as a Stage-Specific Inhibitor of Vaccinia Orthopoxvirus with a potency of 10000.0 nM and shows high inhibition of the Norepinephrine transporter (NET, SLC6A2) with an IC50 of 5.0 nM. In terms of antiviral activity, Nisoxetine hydrochloride has demonstrated varying degrees of inhibition against SARS-CoV-2. It exhibits low activity in inhibiting cell viability in Vero E6 cells infected with SARS-CoV-2 at a low inhibition index of 0.1634 after 72 hours, compared to the control arbidol. It shows 23.34% inhibition of SARS-CoV-2 3CL-Pro protease at 20 µM concentration through a FRET response assay. The compound has also shown to inhibit SARS-CoV-2 induced cytotoxicity in Caco-2 cells with an inhibition rate of 6.1% at 10 µM concentration after 48 hours. Similarly, it inhibits SARS-CoV-2 induced cytotoxicity in VERO-6 cells with an inhibition rate of 0.39% at the same concentration and time point. Lastly, it exhibits low activity in MLPCN SirT-5 assays with an AC50 above 30000.0 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Nisoxetine hydrochloride is a noradrenaline transporter (NET) inhibitor
Targets&IC50	NET:Kd: 0.76 nM

Chemical Properties

Molecular Weight	307.82
Formula	C₁₇H₂₁NO₂·HCl
Cas No.	57754-86-6
Smiles	Cl.CNCCC(Oc1ccccc1OC)c1ccccc1
Relative Density.	1.054g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (146.19 mM), Sonication is recommended.

H2O: < 30.78 mg/mL, Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2487 mL	16.2433 mL	32.4865 mL	162.4326 mL
5 mM	0.6497 mL	3.2487 mL	6.4973 mL	32.4865 mL
10 mM	0.3249 mL	1.6243 mL	3.2487 mL	16.2433 mL
20 mM	0.1624 mL	0.8122 mL	1.6243 mL	8.1216 mL
50 mM	0.0650 mL	0.3249 mL	0.6497 mL	3.2487 mL
100 mM	0.0325 mL	0.1624 mL	0.3249 mL	1.6243 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc