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UC-514321

Name: UC-514321
Brand: TargetMol
SKU: T13950
Price: 68 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T13950Cas No. 299420-83-0

UC-514321 directly targets STAT3/5 and represses TET1 expression. UC-514321 has the potential to treat acute myeloid leukemia (AML) both in vitro and in vivo, with low toxicity.

UC-514321

🥰Excellent

Purity: 98.50%

Catalog No. T13950Cas No. 299420-83-0

UC-514321 directly targets STAT3/5 and represses TET1 expression. UC-514321 has the potential to treat acute myeloid leukemia (AML) both in vitro and in vivo, with low toxicity.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$68	In Stock	In Stock
5 mg	$163	In Stock	In Stock
10 mg	$263	In Stock	In Stock
25 mg	$529	In Stock	In Stock
50 mg	$793	In Stock	In Stock
100 mg	$1,190	In Stock	In Stock
200 mg	$1,630	-	In Stock
1 mL x 10 mM (in DMSO)	$179	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.50%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	UC-514321 directly targets STAT3/5 and represses TET1 expression. UC-514321 has the potential to treat acute myeloid leukemia (AML) both in vitro and in vivo, with low toxicity.
In vitro	UC-514321 (0-500 nM, 48 h) inhibits AML cells viability TET1-signaling dependently.UC-514321 increases apoptosis in AML cells not in normal HSPCs.
In vivo	In AML mice models, UC-514321 (2.5 mg/kg, i.p., once per day, for 10 days) exhibits more potent anti-tumor activity than NSC370284.

Chemical Properties

Molecular Weight	441.56
Formula	C₂₆H₃₅NO₅
Cas No.	299420-83-0
Smiles	CC(C)(C)c1cc(cc(c1O)C(C)(C)C)C(N1CCOCC1)c1cc2OCOc2cc1O
Relative Density.	1.186 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (55.62 mM), Sonication is recommended.

H2O: 50 mg/mL (113.23 mM), Sonication is recommended.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.2647 mL	11.3235 mL	22.6470 mL	113.2349 mL
5 mM	0.4529 mL	2.2647 mL	4.5294 mL	22.6470 mL
10 mM	0.2265 mL	1.1323 mL	2.2647 mL	11.3235 mL
20 mM	0.1132 mL	0.5662 mL	1.1323 mL	5.6617 mL
50 mM	0.0453 mL	0.2265 mL	0.4529 mL	2.2647 mL

H2O

	1mg	5mg	10mg	50mg
100 mM	0.0226 mL	0.1132 mL	0.2265 mL	1.1323 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc