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HLA-G Free Heavy Chain Protein, Human, Recombinant (His & Avi)

Catalog No. TMPK-00836 Copy Product Info
HLA-G is a molecule that was first known to confer protection to the fetus from destruction by the immune system of its mother, thus critically contributing to fetal-maternal tolerance. The first functional finding constituted the basis for HLA-G research and can be summarized as such: HLA-G, membrane-bound or soluble, strongly binds its inhibitory receptors on immune cells (NK, T, B, monocytes/dendritic cells), inhibits the functions of these effectors, and so induces immune inhibition.

HLA-G Free Heavy Chain Protein, Human, Recombinant (His & Avi)

Catalog No. TMPK-00836
Copy Product Info

HLA-G is a molecule that was first known to confer protection to the fetus from destruction by the immune system of its mother, thus critically contributing to fetal-maternal tolerance. The first functional finding constituted the basis for HLA-G research and can be summarized as such: HLA-G, membrane-bound or soluble, strongly binds its inhibitory receptors on immune cells (NK, T, B, monocytes/dendritic cells), inhibits the functions of these effectors, and so induces immune inhibition.

HLA-G Free Heavy Chain Protein, Human, Recombinant (His & Avi)
Pack SizePriceUSA StockGlobal StockQuantity
5 μg$447-10 days7-10 days
10 μg$687-10 days7-10 days
20 μg$1087-10 days7-10 days
50 μg$1987-10 days7-10 days
100 μg$3477-10 days7-10 days
200 μg$6287-10 days7-10 days
500 μg$1,4007-10 days7-10 days
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For In stock only · Estimated delivery:USA Stock (1-2 days) Global Stock (5-7 days)
For research use only—not for human use. No sales to individuals. Use as intended only.
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Batch Information

Product Information

Biological Activity
Immobilized Human HLA-G Free Heavy Chain, His Tag at 2μg/ml (100μl/Well) on the. Dose response curve for Anti-HLA-G Antibody, hFc Tag with the EC50 of 25.9ng/ml determined by ELISA.
Description
HLA-G is a molecule that was first known to confer protection to the fetus from destruction by the immune system of its mother, thus critically contributing to fetal-maternal tolerance. The first functional finding constituted the basis for HLA-G research and can be summarized as such: HLA-G, membrane-bound or soluble, strongly binds its inhibitory receptors on immune cells (NK, T, B, monocytes/dendritic cells), inhibits the functions of these effectors, and so induces immune inhibition.
Species
Human
Expression System
E. coli
TagC-His-Avi
Accession NumberP17693-1
Synonyms
sHLA-G,MHC-G,MHC class Ib antigen,MHC Class I Antigen G,HLA-G,HLAG,HLA G antigen,HLA G,b2 microglobulin
Construction
Gly25-Thr305(C66S)
Protein Purity
> 95% as determined by Tris-Bis PAGE
Molecular Weight35.5 kDa (predicted). The protein migrates to 36-40 kDa based on Tris-Bis PAGE result.
Endotoxin< 1.0 EU/μg of the protein as determined by the LAL method.
FormulationSupplied as 0.22 μm filtered solution in 20 mM Tris, 500 mM NaCl, 20% Glycerol (pH 8.0).
Stability & Storage
It is recommended to store the product under sterile conditions at -70°C or lower. Samples are stable for up to 12 months at -80°C. Please avoid multiple freeze-thaw cycles and store products in aliquots.
ShippingProteins are shipped with blue ice.
Research Background
HLA-G is a molecule that was first known to confer protection to the fetus from destruction by the immune system of its mother, thus critically contributing to fetal-maternal tolerance. The first functional finding constituted the basis for HLA-G research and can be summarized as such: HLA-G, membrane-bound or soluble, strongly binds its inhibitory receptors on immune cells (NK, T, B, monocytes/dendritic cells), inhibits the functions of these effectors, and so induces immune inhibition.

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