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SHP099
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Catalog No. T3564Cas No. 1801747-42-1
Alias SHP099 free base, SHP-099, SHP 099
SHP099 (SHP099 free base) free base is an effective, selective, orally bioavailable, and efficacious SHP2 inhibitor (IC50 =0.07 μM and p-ERK modulation in cells IC50 = 0.250 μM). SHP099 shows dose-dependent pathway inhibition and antitumor activity in xenograft models.
SHP099
Copy Product Info🥰Excellent
Purity: 99.4%
Catalog No. T3564Alias SHP099 free base, SHP-099, SHP 099Cas No. 1801747-42-1
SHP099 (SHP099 free base) free base is an effective, selective, orally bioavailable, and efficacious SHP2 inhibitor (IC50 =0.07 μM and p-ERK modulation in cells IC50 = 0.250 μM). SHP099 shows dose-dependent pathway inhibition and antitumor activity in xenograft models.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $31 | In Stock | In Stock | |
| 2 mg | $44 | In Stock | In Stock | |
| 5 mg | $72 | In Stock | In Stock | |
| 10 mg | $101 | In Stock | In Stock | |
| 25 mg | $177 | In Stock | In Stock | |
| 50 mg | $237 | In Stock | In Stock | |
| 100 mg | $431 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $55 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.4%
Appearance:Solid
Color:White to Yellow
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Product Introduction
SHP099 AI Summary
SHP099 exhibits bioactivity as an allosteric inhibitor of SHP2, including both wild type and E76A mutant forms, with IC50 values of 60.0 nM and 120.0 nM respectively. It shows significant antiproliferative activity against various human cancer cell lines, such as KYSE520, ASPC1, SW1990, BXPC-3, and MV4-11, with IC50 values ranging from 240.0 nM to 104800.0 nM. The compound also demonstrates antiviral activity against SARS-CoV-2, inhibiting virus-induced cytotoxicity in Caco-2 cells by 49.74% at 10 μM concentration after 48 hours. Additionally, SHP099 exhibits oral bioavailability in C57BL/6 mice at 5 mg/kg with a bioavailability percentage of 46.0% and high solubility exceeding 500,000.0 nM at pH 6.8. It also shows inhibition of HDAC6 and displays binding affinity to both wild type and mutant forms of SHP2, significantly inducing cell cycle arrest and enhancing antitumor immunity in mouse models. Overall, SHP099 presents as a promising multi-potent compound with potential applications in cancer therapy and antiviral treatment..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | SHP099 (SHP099 free base) free base is an effective, selective, orally bioavailable, and efficacious SHP2 inhibitor (IC50 =0.07 μM and p-ERK modulation in cells IC50 = 0.250 μM). SHP099 shows dose-dependent pathway inhibition and antitumor activity in xenograft models. |
| Targets&IC50 | SHP2:0.07 μM, pERK:0.250 μM, BXPC-3 cells:72.86 μM, SHP2 (E69K):0.416 μM, TF-1 cell:1.73 μM, 4T1 cells:119.3 μM, SHP2E76K:2.896 μM, ASPC1 cells:64.04 μM, SHP2 (D61Y):1.241 μM, BaF3 cells:19.86 μM, Capan-2 cells:15.67 μM, SHP2A72V:1.968 μM, MV-4-11 cells:0.32 μM |
| Synonyms | SHP099 free base, SHP-099, SHP 099 |
| Molecular Weight | 352.26 |
| Formula | C16H19Cl2N5 |
| Cas No. | 1801747-42-1 |
| Smiles | CC1(N)CCN(CC1)c1cnc(c(N)n1)-c1cccc(Cl)c1Cl |
| Relative Density. | 1.326 g/cm3 (Predicted) |
| Storage | store at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 15.8 mg/mL (44.85 mM), Sonication is recommended.  | |||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2.84 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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