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Anti-Olig-2/Oligo2 Antibody (5L16) is a Rabbit antibody targeting Olig-2/Oligo2. Anti-Olig-2/Oligo2 Antibody (5L16) can be used in WB,IHC-P.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
20 μL | $92 | 7-10 days | |
100 μL | $270 | 7-10 days |
Description | Anti-Olig-2/Oligo2 Antibody (5L16) is a Rabbit antibody targeting Olig-2/Oligo2. Anti-Olig-2/Oligo2 Antibody (5L16) can be used in WB,IHC-P. |
Alias | RACK17, PRKCBP2, OLIGO2, Olig2, bHLHe19, BHLHB1 |
Ig Type | Monoclonal Rabbit IgG |
Clone | 5L16 |
Reactivity | Human |
Verified Activity | 1. Immunochemical staining of human olig-2 in human glioma with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). 2. Immunochemical staining of human olig-2 in human brain with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). 3. Anti-Olig-2 rabbit monoclonal antibody at 1:500 dilution. -Lane A: Jurkat Whole Cell lysate. -Lysates/proteins at 30 μg per lane. -Secondary -Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution. -Developed using the Odyssey technique. -Performed under reducing conditions. -Predicted band size:32 kDa. -Observed band size:37 kDa |
Application | WB,IHC-P |
Recommended Dose | WB: 1:500-1:2000; IHC-P: 1:100-1:500 |
Antibody Type | Monoclonal |
Host Species | Rabbit |
Construction | This antibody was obtained from a rabbit immunized with purified, synthetic peptide corresponding to the N-terminus of the Human Olig-2. |
Purification | Protein A |
Appearance | Liquid |
Formulation | 0.2 μm filtered solution in PBS |
Research Background | Olig2, also known as Oligo2, is a basic helix-loop-helix transcription factor that is expressed in oligodendroglial tumors of the brain. Oligo2 is structurally similar to OLIG1. Both of them have non-overlapping developmental functions in patterning, neuron subtype specification, and the formation of oligodendrocytes. Olig2 is required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Its over-expression inhibits neural progenitor proliferation through changes in potassium channel activity, thereby contributing to the reduced neuronal numbers and brain size in down syndrome. Olig2 may be a cause of a form of T-cell acute lymphoblastic leukemia. |
Conjucates | Unconjugated |
Immunogen | A synthetic peptide corresponding to the N-terminus of the Human Olig-2. |
Antigen Species | Human |
Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
Transport | Shipping with blue ice. |
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