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Echinocystic acid

Name: Echinocystic acid
Brand: TargetMol
SKU: T2866
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2866Cas No. 510-30-5

Echinocystic acid (EA), a natural triterpone enriched in various herbs, shows a range of pharmacological activities including anti-inflammatory and antioxidant effects.

Echinocystic acid

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🥰Excellent

Purity: 99.57%

Catalog No. T2866Cas No. 510-30-5

Echinocystic acid (EA), a natural triterpone enriched in various herbs, shows a range of pharmacological activities including anti-inflammatory and antioxidant effects.

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$34	In Stock	In Stock
25 mg	$67	In Stock	In Stock
50 mg	$95	In Stock	In Stock
100 mg	$138	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.57%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Echinocystic acid AI Summary

Echinocystic acid exhibits a range of biological activities, with significant cytotoxicity against different cell lines and antiviral properties. It shows cytotoxicity against MDCK cells with a CC50 of 15410.0 nM as measured by alamar blue assay after 48 hours and has a selectivity index of 11.0 for HCV pseudoparticles expressing envelope proteins E1 and E2. It demonstrates 40.1% cell viability at 100 µM after 40 hours in MDCK cells using the CellTiter-Glo assay. The compound is effective against HCV, inhibiting pseudoparticle entry into Huh7 cells by 30.7% at 1 µM and 69.6% at 5 µM. Additionally, it inhibits LPS-induced tissue factor procoagulant activity in THP1 cells with an IC50 of 0.054 nM. It shows limited inhibition of SARS-CoV-2 3CL-Pro protease (13.3% at 20 µM) and limited inhibition of SARS-CoV-2 cytotoxicity in VERO-6 cells (0.04% at 10 µM after 48 hours). For the Ebola virus, it demonstrates 2.0% inhibition of pseudoparticle entry into 293T cells at 1 µM after 72 hours. Echinocystic acid also displays anti-necroptotic activity in HT-29 cells with an EC50 greater than 10000.0 nM, and cytotoxicity against SK-OV-3 cells with an IC50 of 96450.0 nM by SRB assay after 48 hours. It can reverse platinum resistance in cisplatin-resistant SK-OV-3 cells, reducing the cisplatin IC50 to 21470.0 nM after 48 hours. Finally, it inhibits SIRT5 with an IC50 of 40000.0 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Echinocystic acid (EA), a natural triterpone enriched in various herbs, shows a range of pharmacological activities including anti-inflammatory and antioxidant effects.

Chemical Properties

Molecular Weight	472.70
Formula	C₃₀H₄₈O₄
Cas No.	510-30-5
Smiles	CC1(C)CCC2(C(O)CC3(C)C(=CCC4C5(C)CCC(O)C(C)(C)C5CCC34C)C2C1)C(O)=O
Relative Density.	1.14g/cm3

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 31.25 mg/mL (66.11 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2.5 mg/mL (5.29 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1155 mL	10.5775 mL	21.1551 mL	105.7753 mL
5 mM	0.4231 mL	2.1155 mL	4.2310 mL	21.1551 mL
10 mM	0.2116 mL	1.0578 mL	2.1155 mL	10.5775 mL
20 mM	0.1058 mL	0.5289 mL	1.0578 mL	5.2888 mL
50 mM	0.0423 mL	0.2116 mL	0.4231 mL	2.1155 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc