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Acetylalkannin

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Catalog No. TN6720Cas No. 34232-27-4
Alias Alkannin acetate, Acetyl alkannin

Acetylalkannin (Alkannin acetate), an isohexenylnaphthazarin pigment extracted from Arnebia euchroma, exhibits antimicrobial and cytotoxic properties.

Acetylalkannin

Acetylalkannin

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Purity: 99.81%
Catalog No. TN6720Alias Alkannin acetate, Acetyl alkanninCas No. 34232-27-4
Acetylalkannin (Alkannin acetate), an isohexenylnaphthazarin pigment extracted from Arnebia euchroma, exhibits antimicrobial and cytotoxic properties.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$45In StockIn Stock
2 mg$64In StockIn Stock
5 mg$106In StockIn Stock
10 mg$156In StockIn Stock
25 mg$247In StockIn Stock
50 mg$367-In Stock
100 mg$542-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:99.81%
Appearance:Solid
Color:Red to Purple
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Product Introduction

Acetylalkannin AI Summary
Acetylalkannin inhibits topoisomerase I with a MIC of 5000.0 nM and exhibits potent antibacterial activity against various strains, including methicillin-resistant Staphylococcus aureus, Staphylococcus aureus, vancomycin-resistant Enterococcus faecalis, and Enterococcus faecium. The compound shows low MIC and MBC values, indicating its effectiveness in inhibiting bacterial growth and killing bacteria. It also demonstrates high cytotoxicity against human cancer cell lines OVCAR-3, HeLa, and HepG2, supported by a significant reduction of bacterial count at 0.5 MIC within 2 hours. Acetylalkannin is cytotoxic against both MDR1 Pgp under-expressing human HCT116 cells and MDR1 Pgp overexpressing human HepG2 cells, with IC50 values of 340.0 nM and 390.0 nM, respectively. It also exhibits varying degrees of cytotoxicity across a range of human and animal cell lines, with an IC50 value as low as 760.0 nM in african green monkey Vero cells and as high as 11530.0 nM in human LNCAP cells, suggesting its broad-spectrum bioactivity..
Note: Summary generated by AI. Data source: ChEMBL
Bioactivity
Description
Acetylalkannin (Alkannin acetate), an isohexenylnaphthazarin pigment extracted from Arnebia euchroma, exhibits antimicrobial and cytotoxic properties.
SynonymsAlkannin acetate, Acetyl alkannin
Chemical Properties
Molecular Weight330.33
FormulaC18H18O6
Cas No.34232-27-4
SmilesCC(C)=CC[C@H](OC(C)=O)C1=CC(=O)c2c(O)ccc(O)c2C1=O
Relative Density.1.326 g/cm3 (Predicted)
Storage & Solubility Information
Storagekeep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 3.31 mg/mL (10.02 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (3.03 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.0273 mL15.1364 mL30.2728 mL151.3638 mL
5 mM0.6055 mL3.0273 mL6.0546 mL30.2728 mL
10 mM0.3027 mL1.5136 mL3.0273 mL15.1364 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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