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Chrysin

Name: Chrysin
Brand: TargetMol
SKU: T2837
Price: 42 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2837Cas No. 480-40-0

Alias NSC 407436, 5,7-Dihydroxyflavone, 5, 7-Dihydroxyflavone

Chrysin (5,7-Dihydroxyflavone) exhibits many biological activities and pharmacological effects, including antioxidant, anti-inflammatory, anticancer, and antiviral activities.

Chrysin

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Purity: 99.75%

Catalog No. T2837Alias NSC 407436, 5,7-Dihydroxyflavone, 5, 7-DihydroxyflavoneCas No. 480-40-0

Chrysin (5,7-Dihydroxyflavone) exhibits many biological activities and pharmacological effects, including antioxidant, anti-inflammatory, anticancer, and antiviral activities.

Pack Size	Price	USA Warehouse	Global Warehouse
500 mg	$42	In Stock	In Stock
1 g	$50	-	In Stock
1 mL x 10 mM (in DMSO)	$46	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.75%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR HPLC

Product Introduction

Chrysin AI Summary

Chrysin exhibits a multifaceted bioactivity profile, demonstrating potential in various therapeutic and research applications. It acts as an in vitro inhibitor of human gastric adenocarcinoma SGC-7901 and colorectal adenocarcinoma HT-29 cell lines, with IC50 values of 5800.0 nM and 3100.0 nM, respectively, suggesting its potential as an anti-cancer agent. In vivo, it shows hypoglycemic activity in mice at 45 mg/kg, reducing blood glucose levels, and has a significant therapeutic index against H9 cells in HIV1 infection, with EC50 of 5.0 µg/mL and a therapeutic index of 9.0, indicating favorable safety margins. The compound inhibits various enzymes, including aldose reductase (IC50 of 8500.0 nM), xanthine oxidase (IC50 of 840.0 nM), and recombinant human carbonic anhydrases with Ki values between 2650.0 nM to 9070.0 nM. Additionally, it shows antioxidant properties by inhibiting ROS production in bone marrow cells (IC25 of 4480.0 µM). In enzymatic inhibition, Chrysin targets CYP1A1, CYP1A2, and CYP1B1 cytochrome P450 enzymes with IC50 values of 153.0 nM, 84.0 nM, and 24.0 nM, respectively. It also inhibits PIM1 kinase with an IC50 of -1.18 µM and COX2 with significant inhibition of 74.0% at 100 uM. Antibacterial activity is noted, with moderate efficacy against strains like Staphylococcus aureus (MIC of 25.0 - 50.0 µg/mL). The compound exhibits an affinity towards various receptors, including the benzodiazepine site of GABA_A (Ki of 920.0 nM) and PPAR receptors showing agonist activity with notable fold changes at varying concentrations. It also demonstrates interactions with p-glycoprotein, affecting daunomycin accumulation due to hydrophobic properties (logP value of 5.7). In antiviral assays, Chrysin shows activity against HIV1 and Chikungunya virus with IC50 values of 5000.0 nM and 22500.0 nM, respectively. It also exhibits selectivity against Trypanosoma cruzi trans-sialidase and moderate effectiveness against influenza neuraminidase. Overall, Chrysin shows significant potential in multiple applications due to its diverse bioactivities, including anti-cancer, hypoglycemic, antiviral, antibacterial, and enzyme inhibition properties..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Chrysin (5,7-Dihydroxyflavone) exhibits many biological activities and pharmacological effects, including antioxidant, anti-inflammatory, anticancer, and antiviral activities.
Synonyms	NSC 407436, 5,7-Dihydroxyflavone, 5, 7-Dihydroxyflavone

Chemical Properties

Molecular Weight	254.24
Formula	C₁₅H₁₀O₄
Cas No.	480-40-0
Smiles	OC1=CC(O)=C2C(=O)C=C(OC2=C1)C1=CC=CC=C1
Relative Density.	1.2693 g/cm3 (Estimated)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 130 mg/mL (511.33 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.87 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.9333 mL	19.6665 mL	39.3329 mL	196.6646 mL
5 mM	0.7867 mL	3.9333 mL	7.8666 mL	39.3329 mL
10 mM	0.3933 mL	1.9666 mL	3.9333 mL	19.6665 mL
20 mM	0.1967 mL	0.9833 mL	1.9666 mL	9.8332 mL
50 mM	0.0787 mL	0.3933 mL	0.7867 mL	3.9333 mL
100 mM	0.0393 mL	0.1967 mL	0.3933 mL	1.9666 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc