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Grepafloxacin

Catalog No. T38586 CAS 119914-60-2

Synonyms: dl-Grepafloxacin, OPC-17116

Grepafloxacin (OPC-17116) is a fluoroquinolone antibiotic that is administered orally. It possesses strong efficacy against community-acquired respiratory pathogens, notably Streptococcus pneumonia. Grepafloxacin exhibits excellent tissue penetration and demonstrates a promising pharmacodynamic profile.

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Grepafloxacin, CAS 119914-60-2

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Grepafloxacin (OPC-17116) is a fluoroquinolone antibiotic that is administered orally. It possesses strong efficacy against community-acquired respiratory pathogens, notably Streptococcus pneumonia. Grepafloxacin exhibits excellent tissue penetration and demonstrates a promising pharmacodynamic profile.
In vitro	Grepafloxacin is a once-daily fluoroquinolone[2]. Grepafloxacin exhibits potent in vitro antibacterial activity against Gram-positive bacteria such as Streptococcus pneumoniae and high in vivo efficacy on the experimental systemic infections caused by the Gram-positive and -negative bacteria tested[4].
In vivo	Grepafloxacin (OPC-17116) (200 mg/kg; p.o.; Balb/c mice) displays good safety profile in terms of phototoxicity[2]. Grepafloxacin (p.o.; 25, 50, 100, and 200 mg/kg; 5 days/week for 4 weeks; Female C57BL6/J-Lyst bg-J/ mice/beige mice) has modest activities in both intranasal (IN) infection and intravenous (IV) Mycobacterium avium infection models[3].

Synonyms	dl-Grepafloxacin, OPC-17116
Molecular Weight	359.401
Formula	C19H22FN3O3
CAS No.	119914-60-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Efthymiopoulos C. Pharmacokinetics of grepafloxacin. J Antimicrob Chemother. 1997;40 Suppl A:35-43. 2. Owen K. Comparative grepafloxacin phototoxicity in mouse skin. J Antimicrob Chemother. 1998;42(2):261-264. 3. Cynamon MH, et al. The activity of grepafloxacin in two murine models of Mycobacterium avium infection. J Infect Chemother. 2004;10(3):185-188. 4. Miyamoto H, et al. Synthesis and biological properties of substituted 1,4-dihydro-5-methyl-4-oxo-3-quinolinecarboxylic acids. Bioorg Med Chem. 1995;3(12):1699-1706.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Grepafloxacin 119914-60-2 dl-Grepafloxacin OPC 17116 OPC-17116 OPC17116 inhibitor inhibit

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